DegronMD - Q3SX64(ODF3L2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A160V	TCGA-BP-4161	KIRC	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.A160V	TCGA-BP-4161	KIRC	TCGA	NAYTMPP	CBL_PTK	162:168	Mutation rewiring degron network	0.2778
p.A160V	DO17769	KIRC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.A160V	DO17769	KIRC	ICGC	NAYTMPP	CBL_PTK	162:168	Mutation rewiring degron network	0.2778
p.A160V	DO229272	THCA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.A160V	DO229272	THCA	ICGC	NAYTMPP	CBL_PTK	162:168	Mutation rewiring degron network	0.2778
p.R148C	TCGA-CK-5913	COAD	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8301
p.R148C	DO8826	COAD	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8301
p.R148C	DO233898	GACA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8301
p.L149F	TCGA-D1-A16F	UCEC	TCGA	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.587
p.L149F	DO42408	UCEC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.587
p.P159H	DO233903	GACA	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2222
p.P159H	DO233903	GACA	ICGC	NAYTMPP	CBL_PTK	162:168	Mutation rewiring degron network	0.25
p.P140L	DO43418	UCEC	ICGC	CRLPLKPLD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons