DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NAYTMPP
Uniprot ID:
Q3SX64
Source protein:
Outer dense fiber protein 3-like protein 2
Source gene:
ODF3L2
Class:
CBL_PTK
Location:
162:168
E3 ligase:
CBL
DEGRON score:
0.7594
ASA_SCORE:
42.8143
COIL:
0.7047
CONS_SCORE:
0.7039
DSS_SCORE:
0.4327
HELIX:
0.0789
FCONS_SCORE:
1.0893
RIG_SCORE:
0.7454
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A160V
TCGA-BP-4161
KIRC
TCGA
NAYTMPP
CBL_PTK
0.2778
p.A160V
DO17769
KIRC
ICGC
NAYTMPP
CBL_PTK
0.2778
p.A160V
DO229272
THCA
ICGC
NAYTMPP
CBL_PTK
0.2778
p.P159H
DO233903
GACA
ICGC
NAYTMPP
CBL_PTK
0.25
Drug responses associated with ODF3L2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NAYTMPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q3SX64
Outer dense fiber protein 3-like protein 2
CBL_PTK
162:168
NAYTMPP
CBL
0.7594
More...
