DegronMD

Uniprot ID: P53618

Source protein: Coatomer subunit beta

Source gene: COPB1

Class: DEG_APCC_DBOX_1

Location: 635:643

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6948

ASA_SCORE: 56.8111

COIL: 0.1429

CONS_SCORE: 0.3816

DSS_SCORE: 0.2955

HELIX: 0.8539

FCONS_SCORE: 1.1277

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D629N	TCGA-18-3415	LUSC	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	0.1667
p.D629N	DO26427	LUSC	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	0.1667
p.E648K	TCGA-AG-4015	READ	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	0.1944
p.E648K	DO36459	READ	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	0.1944
p.K651N	TCGA-AX-A2HC	UCEC	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	0.5556
p.K651N	DO41572	UCEC	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	0.5556
p.L652V	DO222798	COCA	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	0.0833
p.D629E	DO229045	LICA	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53618	Coatomer subunit beta	DEG_APCC_DBOX_1	635:643	CRQSLSHML	APC,CDC20,FZR1	0.6948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons