DegronMD - P53618(COPB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D629N	TCGA-18-3415	LUSC	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667
p.D629N	DO26427	LUSC	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667
p.L462M	TCGA-A5-A1OF	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.5999
p.L462M	DO42568	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.5999
p.E648K	TCGA-AG-4015	READ	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1944
p.E648K	DO36459	READ	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1944
p.K651N	TCGA-AX-A2HC	UCEC	TCGA	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation blocking ubiquitination signal	0.5556
p.K651N	DO41572	UCEC	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation blocking ubiquitination signal	0.5556
p.T468A	TCGA-DF-A2KU	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation blocking phosphorylation signal	0.6389
p.T468A	DO223286	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation blocking phosphorylation signal	0.6389
p.W460L	TCGA-FI-A2D5	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.5904
p.W460L	DO41331	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation altering degron motif	0.5904
p.S451C	TCGA-HE-7130	KIRP	TCGA	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation blocking phosphorylation signal	0.6667
p.S451C	DO20776	KIRP	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation blocking phosphorylation signal	0.6667
p.A448V	TCGA-W3-AA1V	SKCM	TCGA	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1389
p.A448V	DO51276	SKCM	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1389
p.Q473H	DO1076	BRCA	ICGC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.0556
p.L652V	DO222798	COCA	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.0833
p.D629E	DO229045	LICA	ICGC	CRQSLSHML	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667
p.E470K	SIDM01171	Glioblastoma	GDSC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1389
p.E470K	ACH-000571	Brain Cancer	CCLE	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1389
p.E470K	T98G	central nervous system	COSMIC	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation rewiring degron network	0.1389
p.K450Q	ACH-000773	Lymphoma	CCLE	YRGALWILG	DEG_APCC_DBOX_1	455:463	Mutation substituting flanking lysine	0.3056

Kaplan plot for COPB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COPB1

UniProt ID: P53618

Entrez ID: 1315

Protein name: Coatomer subunit beta (Beta-coat protein) (Beta-COP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COPB1 in