DegronMD

Uniprot ID: P53618

Source protein: Coatomer subunit beta

Source gene: COPB1

Class: DEG_APCC_DBOX_1

Location: 455:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.746

ASA_SCORE: 12.1667

COIL: 0.0153

CONS_SCORE: 0.5685

DSS_SCORE: 0.0148

HELIX: 0.98

FCONS_SCORE: 1.2848

RIG_SCORE: 0.9323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L462M	TCGA-A5-A1OF	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	0.5999
p.L462M	DO42568	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.5999
p.T468A	TCGA-DF-A2KU	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	0.6389
p.T468A	DO223286	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.6389
p.W460L	TCGA-FI-A2D5	UCEC	TCGA	YRGALWILG	DEG_APCC_DBOX_1	0.5904
p.W460L	DO41331	UCEC	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.5904
p.S451C	TCGA-HE-7130	KIRP	TCGA	YRGALWILG	DEG_APCC_DBOX_1	0.6667
p.S451C	DO20776	KIRP	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.6667
p.A448V	TCGA-W3-AA1V	SKCM	TCGA	YRGALWILG	DEG_APCC_DBOX_1	0.1389
p.A448V	DO51276	SKCM	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.1389
p.Q473H	DO1076	BRCA	ICGC	YRGALWILG	DEG_APCC_DBOX_1	0.0556
p.E470K	SIDM01171	Glioblastoma	GDSC	YRGALWILG	DEG_APCC_DBOX_1	0.1389
p.E470K	ACH-000571	Brain Cancer	CCLE	YRGALWILG	DEG_APCC_DBOX_1	0.1389
p.E470K	T98G	central_nervous_system	COSMIC	YRGALWILG	DEG_APCC_DBOX_1	0.1389
p.K450Q	ACH-000773	Lymphoma	CCLE	YRGALWILG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53618	Coatomer subunit beta	DEG_APCC_DBOX_1	455:463	YRGALWILG	APC,CDC20,FZR1	0.746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons