DegronMD

Uniprot ID: Q9UKP4

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 7

Source gene: ADAMTS7

Class: DEG_APCC_DBOX_1

Location: 994:1002

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.804

ASA_SCORE: 72.4111

COIL: 0.8502

CONS_SCORE: 0.2838

DSS_SCORE: 0.3166

HELIX: 0.0213

FCONS_SCORE: 0.9221

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1009S	TCGA-BR-8680	STAD	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	0.1389
p.G1009S	DO47769	STAD	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	0.1389
p.P1003H	TCGA-CC-A7IK	LIHC	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.P1003H	DO52184	LIHC	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.L1001V	TCGA-WN-A9G9	KIRP	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	0.5654
p.L1001V	DO51569	KIRP	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	0.5654
p.G1005V	SIDM01119	Other Solid Cancers	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.25
p.G1005V	ACH-000775	Lung Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	0.25
p.G1005V	NCI-H727	lung	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	0.25
p.E1004D	SIDM00193	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.2778
p.E1004D	ACH-000991	Colon/Colorectal Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	0.2778
p.E1004D	SNU-81	large_intestine	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	0.2778
p.R995W	SIDM01168	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.8634
p.L993P	SIDM01168	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.L993P	SIDM01735	Biliary Tract Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.L993P	ACH-000641	Leukemia	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.L993P	ACH-001036	Leukemia	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.L993P	ACH-001664	Gastric Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	0.3056
p.G999D	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.6087
p.G999D	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.6087
p.G999D	SIDM01735	Biliary Tract Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.6087
p.E986K	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	0.1111
p.E986K	PC-3_[JPC-3]	lung	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKP4	A disintegrin and metalloproteinase with thrombospondin motifs 7	DEG_APCC_DBOX_1	994:1002	CRWPLGTLG	APC,CDC20,FZR1	0.804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRWPLGTLG

Degron related mutations and impact score

Drug responses associated with ADAMTS7 mutations

All proteins holding degron of CRWPLGTLG