DegronMD - Q9UKP4(ADAMTS7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1009S	TCGA-BR-8680	STAD	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.1389
p.G1009S	DO47769	STAD	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.1389
p.P1003H	TCGA-CC-A7IK	LIHC	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.P1003H	DO52184	LIHC	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.A78V	TCGA-DM-A28K	COAD	TCGA	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1667
p.A78V	DO8167	COAD	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1667
p.A78V	DO227780	PBCA	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1667
p.R92H	TCGA-OR-A5JU	ACC	TCGA	LQYRGRELR	SCF_FBXL2	84:92	Mutation altering degron motif	0.7133
p.L1001V	TCGA-WN-A9G9	KIRP	TCGA	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.5654
p.L1001V	DO51569	KIRP	ICGC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.5654
p.R75C	DO10324	COAD	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.0833
p.L91Q	DO233284	GACA	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation altering degron motif	0.6654
p.R87H	DO231631	LINC	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation altering degron motif	0.8244
p.G88R	DO51467	PACA	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation altering degron motif	0.7568
p.A78T	DO51960	PRAD	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1667
p.A78S	DO229216	THCA	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1667
p.P79S	DO229248	THCA	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.1944
p.Y86H	DO42256	UCEC	ICGC	LQYRGRELR	SCF_FBXL2	84:92	Mutation altering degron motif	0.6118
p.E83K	SIDM02049	Pancreatic Carcinoma	GDSC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.3056
p.G1005V	SIDM01119	Other Solid Cancers	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.25
p.G1005V	ACH-000775	Lung Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.25
p.G1005V	NCI-H727	lung	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.25
p.E1004D	SIDM00193	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.2778
p.E1004D	ACH-000991	Colon/Colorectal Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.2778
p.E1004D	SNU-81	large intestine	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.2778
p.R995W	SIDM01168	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.8634
p.L993P	SIDM01168	Colorectal Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.L993P	SIDM01735	Biliary Tract Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.L993P	ACH-000641	Leukemia	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.L993P	ACH-001036	Leukemia	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.L993P	ACH-001664	Gastric Cancer	CCLE	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.3056
p.G999D	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.6087
p.G999D	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.6087
p.G999D	SIDM01735	Biliary Tract Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation altering degron motif	0.6087
p.N94S	SIDM00292	Small Cell Lung Carcinoma	GDSC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.2778
p.N94S	ACH-002077	Lung Cancer	CCLE	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.2778
p.N94S	LU-165	lung	COSMIC	LQYRGRELR	SCF_FBXL2	84:92	Mutation rewiring degron network	0.2778
p.E986K	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.1111
p.E986K	PC-3_[JPC-3]	lung	COSMIC	CRWPLGTLG	DEG_APCC_DBOX_1	994:1002	Mutation rewiring degron network	0.1111

Kaplan plot for ADAMTS7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS7

UniProt ID: Q9UKP4

Entrez ID: 11173

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ADAMTS7 in