DegronMD

Uniprot ID: Q9UKP4

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 7

Source gene: ADAMTS7

Class: SCF_FBXL2

Location: 84:92

E3 ligase: FBXL2

DEGRON score: 0.9072

ASA_SCORE: 67.6

COIL: 0.231

CONS_SCORE: 0.3126

DSS_SCORE: 0.1345

HELIX: 0.0009

FCONS_SCORE: 1.2617

RIG_SCORE: 0.8367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A78V	TCGA-DM-A28K	COAD	TCGA	LQYRGRELR	SCF_FBXL2	0.1667
p.A78V	DO8167	COAD	ICGC	LQYRGRELR	SCF_FBXL2	0.1667
p.A78V	DO227780	PBCA	ICGC	LQYRGRELR	SCF_FBXL2	0.1667
p.R92H	TCGA-OR-A5JU	ACC	TCGA	LQYRGRELR	SCF_FBXL2	0.7133
p.R75C	DO10324	COAD	ICGC	LQYRGRELR	SCF_FBXL2	0.0833
p.L91Q	DO233284	GACA	ICGC	LQYRGRELR	SCF_FBXL2	0.6654
p.R87H	DO231631	LINC	ICGC	LQYRGRELR	SCF_FBXL2	0.8244
p.G88R	DO51467	PACA	ICGC	LQYRGRELR	SCF_FBXL2	0.7568
p.A78T	DO51960	PRAD	ICGC	LQYRGRELR	SCF_FBXL2	0.1667
p.A78S	DO229216	THCA	ICGC	LQYRGRELR	SCF_FBXL2	0.1667
p.P79S	DO229248	THCA	ICGC	LQYRGRELR	SCF_FBXL2	0.1944
p.Y86H	DO42256	UCEC	ICGC	LQYRGRELR	SCF_FBXL2	0.6118
p.E83K	SIDM02049	Pancreatic Carcinoma	GDSC	LQYRGRELR	SCF_FBXL2	0.3056
p.N94S	SIDM00292	Small Cell Lung Carcinoma	GDSC	LQYRGRELR	SCF_FBXL2	0.2778
p.N94S	ACH-002077	Lung Cancer	CCLE	LQYRGRELR	SCF_FBXL2	0.2778
p.N94S	LU-165	lung	COSMIC	LQYRGRELR	SCF_FBXL2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKP4	A disintegrin and metalloproteinase with thrombospondin motifs 7	SCF_FBXL2	84:92	LQYRGRELR	FBXL2	0.9072	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons