DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
CRYDLAEIQ
Uniprot ID:
Q9NTN9
Source protein:
Semaphorin-4G
Source gene:
SEMA4G
Class:
DEG_APCC_DBOX_1
Location:
337:345
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8175
ASA_SCORE:
46.6778
COIL:
0.1129
CONS_SCORE:
0.5569
DSS_SCORE:
0.049
HELIX:
0.5564
FCONS_SCORE:
1.3381
RIG_SCORE:
0.9536
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R338H
TCGA-ER-A3ES
SKCM
TCGA
CRYDLAEIQ
DEG_APCC_DBOX_1
0.8244
p.R338H
DO227657
COCA
ICGC
CRYDLAEIQ
DEG_APCC_DBOX_1
0.8244
p.R338H
DO47546
SKCM
ICGC
CRYDLAEIQ
DEG_APCC_DBOX_1
0.8244
p.G350E
DO222595
MELA
ICGC
CRYDLAEIQ
DEG_APCC_DBOX_1
0.1944
p.L331V
SIDM01735
Biliary Tract Carcinoma
GDSC
CRYDLAEIQ
DEG_APCC_DBOX_1
0.1667
p.L331V
SIDM01473
Plasma Cell Myeloma
GDSC
CRYDLAEIQ
DEG_APCC_DBOX_1
0.1667
p.Q345H
ACH-001719
Ovarian Cancer
CCLE
CRYDLAEIQ
DEG_APCC_DBOX_1
0.647
Drug responses associated with SEMA4G mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of CRYDLAEIQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NTN9
Semaphorin-4G
DEG_APCC_DBOX_1
337:345
CRYDLAEIQ
APC,CDC20,FZR1
0.8175
More...