DegronMD

Uniprot ID: Q9NTN9

Source protein: Semaphorin-4G

Source gene: SEMA4G

Class: DEG_APCC_DBOX_1

Location: 337:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8175

ASA_SCORE: 46.6778

COIL: 0.1129

CONS_SCORE: 0.5569

DSS_SCORE: 0.049

HELIX: 0.5564

FCONS_SCORE: 1.3381

RIG_SCORE: 0.9536

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R338H	TCGA-ER-A3ES	SKCM	TCGA	CRYDLAEIQ	DEG_APCC_DBOX_1	0.8244
p.R338H	DO227657	COCA	ICGC	CRYDLAEIQ	DEG_APCC_DBOX_1	0.8244
p.R338H	DO47546	SKCM	ICGC	CRYDLAEIQ	DEG_APCC_DBOX_1	0.8244
p.Q345H	ACH-001719	Ovarian Cancer	CCLE	CRYDLAEIQ	DEG_APCC_DBOX_1	0.647
p.G350E	DO222595	MELA	ICGC	CRYDLAEIQ	DEG_APCC_DBOX_1	0.1944
p.L331V	SIDM01735	Biliary Tract Carcinoma	GDSC	CRYDLAEIQ	DEG_APCC_DBOX_1	0.1667
p.L331V	SIDM01473	Plasma Cell Myeloma	GDSC	CRYDLAEIQ	DEG_APCC_DBOX_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTN9	Semaphorin-4G	DEG_APCC_DBOX_1	337:345	CRYDLAEIQ	APC,CDC20,FZR1	0.8175	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons