DegronMD

Uniprot ID: Q5QJ38

Source protein: Trichohyalin-like protein 1

Source gene: TCHHL1

Class: DEG_SCF_SKP2-CKS1_1

Location: 339:346

E3 ligase: SKP2,CSK1

DEGRON score: 0.5455

ASA_SCORE: 95.3

COIL: 0.9089

CONS_SCORE: 0.4147

DSS_SCORE: 0.7414

HELIX: 0.0671

FCONS_SCORE: 0.8815

RIG_SCORE: 0.6507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L350F	TCGA-55-8514	LUAD	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.L350F	TCGA-90-7769	LUSC	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.L350F	DO23616	LUAD	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.L350F	DO26822	LUSC	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D332G	TCGA-AG-A002	READ	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E354Q	TCGA-CR-7388	HNSC	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E354Q	DO14284	HNSC	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.D339N	TCGA-W3-AA1V	SKCM	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.5821
p.D339N	DO51276	SKCM	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.5821
p.P353L	TCGA-WE-A8ZO	SKCM	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P353L	DO51286	SKCM	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.D355N	DO229453	SKCA	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T347S	DO229456	SKCA	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A345V	SIDM00120	Prostate Carcinoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.5825
p.A345V	ACH-000979	Prostate Cancer	CCLE	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.5825
p.A345V	DU-145	prostate	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.5825
p.G351C	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.G351C	ACH-000853	Lung Cancer	CCLE	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.G351C	NCI-H661	lung	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K348N	SIDM00801	Melanoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K348N	A101D	skin	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJ38	Trichohyalin-like protein 1	DEG_SCF_SKP2-CKS1_1	339:346	DADQTPAK	SKP2,CSK1	0.5455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons