DegronMD - Q5QJ38(TCHHL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G571R	TCGA-18-3409	LUSC	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.1944
p.G571R	DO26444	LUSC	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.1944
p.P649H	TCGA-33-4566	LUSC	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.7694
p.P649H	DO26790	LUSC	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.7694
p.G558C	TCGA-55-8507	LUAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.25
p.G558C	DO45412	LUAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.25
p.L350F	TCGA-55-8514	LUAD	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2222
p.L350F	TCGA-90-7769	LUSC	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2222
p.L350F	DO23616	LUAD	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2222
p.L350F	DO26822	LUSC	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2222
p.G637V	TCGA-80-5608	LUAD	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.G637V	DO23693	LUAD	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.S552R	TCGA-AA-3966	COAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.0833
p.S552R	DO10068	COAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.0833
p.D332G	TCGA-AG-A002	READ	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1389
p.P638T	TCGA-AP-A051	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.2222
p.P638T	DO42673	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.2222
p.P568L	TCGA-AP-A059	UCEC	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.2778
p.P568L	DO41361	UCEC	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.2778
p.G637D	TCGA-AX-A0J1	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.G637D	DO41199	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.E632K	TCGA-BF-AAP1	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.E632K	DO219464	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.S552G	TCGA-BR-6452	STAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.0833
p.S552G	DO38404	STAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.0833
p.E563K	TCGA-C5-A905	CESC	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation altering degron motif	0.7022
p.E563K	DO49918	CESC	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation altering degron motif	0.7022
p.E354Q	TCGA-CR-7388	HNSC	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1111
p.E354Q	DO14284	HNSC	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1111
p.N650S	TCGA-D1-A167	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.5958
p.N650S	DO40978	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.5958
p.G639E	TCGA-D3-A51R	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.25
p.G639E	DO47480	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.25
p.E556Q	TCGA-DK-A6B6	BLCA	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.1944
p.E556Q	DO48366	BLCA	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.1944
p.E556Q	DO48576	BLCA	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.1944
p.G637S	TCGA-EE-A3AA	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.G637S	DO222632	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.G637S	DO37571	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.S561N	TCGA-GN-A269	SKCM	TCGA	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation altering degron motif	0.5958
p.S561N	DO37483	SKCM	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation altering degron motif	0.5958
p.D339N	TCGA-W3-AA1V	SKCM	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation altering degron motif	0.5821
p.D339N	DO51276	SKCM	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation altering degron motif	0.5821
p.P353L	TCGA-WE-A8ZO	SKCM	TCGA	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1389
p.P353L	DO51286	SKCM	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1389
p.G651V	DO222404	BTCA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.3056
p.H633N	DO228952	LICA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0833
p.Q576K	DO228971	LICA	ICGC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.0556
p.E632G	DO229062	LICA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.A660S	DO220906	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.S658F	DO222653	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1111
p.E657K	DO222843	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1389
p.D355N	DO229453	SKCA	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.0833
p.T347S	DO229456	SKCA	ICGC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.3056
p.A345V	SIDM00120	Prostate Carcinoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation altering degron motif	0.5825
p.A345V	ACH-000979	Prostate Cancer	CCLE	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation altering degron motif	0.5825
p.A345V	DU-145	prostate	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation altering degron motif	0.5825
p.G351C	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1944
p.G351C	ACH-000853	Lung Cancer	CCLE	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1944
p.G351C	NCI-H661	lung	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.1944
p.T659R	SIDM00294	Small Cell Lung Carcinoma	GDSC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0833
p.T659R	ACH-001549	Lung Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0833
p.T659R	LU-135	lung	COSMIC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0833
p.K348N	SIDM00801	Melanoma	GDSC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2778
p.K348N	A101D	skin	COSMIC	DADQTPAK	DEG_SCF_SKP2-CKS1_1	339:346	Mutation rewiring degron network	0.2778
p.G642D	SIDM00003	Melanoma	GDSC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.6087
p.G642D	ACH-002159	Skin Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.6087
p.G642D	M14	skin	COSMIC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.6087
p.A645G	SIDM00247	Gastric Carcinoma	GDSC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.754
p.A645G	ACH-000356	Gastric Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.754
p.A645G	MKN45	stomach	COSMIC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation altering degron motif	0.754
p.P653L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.25
p.P653L	ACH-000937	Leukemia	CCLE	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.25
p.P653L	PF-382	haematopoietic and lymphoid tissue	COSMIC	GPGAAVEPN	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.25
p.E557Q	SIDM01587	Bladder Carcinoma	GDSC	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.2222
p.E557Q	ACH-000753	Bladder Cancer	CCLE	SSETGE	DEG_Kelch_Keap1_1	561:566	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCHHL1

UniProt ID: Q5QJ38

Entrez ID: 126637

Protein name: Trichohyalin-like protein 1 (Basalin) (Protein S100-A17) (S100 calcium-binding protein A17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCHHL1 in