DegronMD

Uniprot ID: Q5QJ38

Source protein: Trichohyalin-like protein 1

Source gene: TCHHL1

Class: DEG_Kelch_Keap1_1

Location: 561:566

E3 ligase: KEAP1

DEGRON score: 0.7678

ASA_SCORE: 96.5333

COIL: 0.9377

CONS_SCORE: 0.7481

DSS_SCORE: 0.884

HELIX: 0.0478

FCONS_SCORE: 1.0281

RIG_SCORE: 0.5543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G571R	TCGA-18-3409	LUSC	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.1944
p.G571R	DO26444	LUSC	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.1944
p.G558C	TCGA-55-8507	LUAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.25
p.G558C	DO45412	LUAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.25
p.S552R	TCGA-AA-3966	COAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.0833
p.S552R	DO10068	COAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.0833
p.P568L	TCGA-AP-A059	UCEC	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.2778
p.P568L	DO41361	UCEC	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.2778
p.S552G	TCGA-BR-6452	STAD	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.0833
p.S552G	DO38404	STAD	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.0833
p.E563K	TCGA-C5-A905	CESC	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.7022
p.E563K	DO49918	CESC	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.7022
p.E556Q	TCGA-DK-A6B6	BLCA	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.1944
p.E556Q	DO48366	BLCA	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.1944
p.E556Q	DO48576	BLCA	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.1944
p.S561N	TCGA-GN-A269	SKCM	TCGA	SSETGE	DEG_Kelch_Keap1_1	0.5958
p.S561N	DO37483	SKCM	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.5958
p.Q576K	DO228971	LICA	ICGC	SSETGE	DEG_Kelch_Keap1_1	0.0556
p.E557Q	SIDM01587	Bladder Carcinoma	GDSC	SSETGE	DEG_Kelch_Keap1_1	0.2222
p.E557Q	ACH-000753	Bladder Cancer	CCLE	SSETGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJ38	Trichohyalin-like protein 1	DEG_Kelch_Keap1_1	561:566	SSETGE	KEAP1	0.7678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons