DegronMD

Uniprot ID: Q5QJ38

Source protein: Trichohyalin-like protein 1

Source gene: TCHHL1

Class: DEG_SIAH_1

Location: 642:650

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9699

ASA_SCORE: 91.8333

COIL: 0.9548

CONS_SCORE: 0.7411

DSS_SCORE: 0.8798

HELIX: 0.0249

FCONS_SCORE: 1.1389

RIG_SCORE: 0.5224

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P649H	TCGA-33-4566	LUSC	TCGA	GPGAAVEPN	DEG_SIAH_1	0.7694
p.P649H	DO26790	LUSC	ICGC	GPGAAVEPN	DEG_SIAH_1	0.7694
p.G637V	TCGA-80-5608	LUAD	TCGA	GPGAAVEPN	DEG_SIAH_1	0.1944
p.G637V	DO23693	LUAD	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1944
p.P638T	TCGA-AP-A051	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	0.2222
p.P638T	DO42673	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	0.2222
p.G637D	TCGA-AX-A0J1	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	0.1944
p.G637D	DO41199	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1944
p.E632K	TCGA-BF-AAP1	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	0.0556
p.E632K	DO219464	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	0.0556
p.N650S	TCGA-D1-A167	UCEC	TCGA	GPGAAVEPN	DEG_SIAH_1	0.5958
p.N650S	DO40978	UCEC	ICGC	GPGAAVEPN	DEG_SIAH_1	0.5958
p.G639E	TCGA-D3-A51R	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	0.25
p.G639E	DO47480	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	0.25
p.G637S	TCGA-EE-A3AA	SKCM	TCGA	GPGAAVEPN	DEG_SIAH_1	0.1944
p.G637S	DO222632	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1944
p.G637S	DO37571	SKCM	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1944
p.G651V	DO222404	BTCA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.3056
p.H633N	DO228952	LICA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.0833
p.E632G	DO229062	LICA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.0556
p.A660S	DO220906	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.0556
p.S658F	DO222653	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1111
p.E657K	DO222843	MELA	ICGC	GPGAAVEPN	DEG_SIAH_1	0.1389
p.T659R	SIDM00294	Small Cell Lung Carcinoma	GDSC	GPGAAVEPN	DEG_SIAH_1	0.0833
p.T659R	ACH-001549	Lung Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	0.0833
p.T659R	LU-135	lung	COSMIC	GPGAAVEPN	DEG_SIAH_1	0.0833
p.G642D	SIDM00003	Melanoma	GDSC	GPGAAVEPN	DEG_SIAH_1	0.6087
p.G642D	ACH-002159	Skin Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	0.6087
p.G642D	M14	skin	COSMIC	GPGAAVEPN	DEG_SIAH_1	0.6087
p.A645G	SIDM00247	Gastric Carcinoma	GDSC	GPGAAVEPN	DEG_SIAH_1	0.754
p.A645G	ACH-000356	Gastric Cancer	CCLE	GPGAAVEPN	DEG_SIAH_1	0.754
p.A645G	MKN45	stomach	COSMIC	GPGAAVEPN	DEG_SIAH_1	0.754
p.P653L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GPGAAVEPN	DEG_SIAH_1	0.25
p.P653L	ACH-000937	Leukemia	CCLE	GPGAAVEPN	DEG_SIAH_1	0.25
p.P653L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	GPGAAVEPN	DEG_SIAH_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GPGAAVEPN

Degron related mutations and impact score

Drug responses associated with TCHHL1 mutations

All proteins holding degron of GPGAAVEPN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJ38	Trichohyalin-like protein 1	DEG_SIAH_1	642:650	GPGAAVEPN	SIAH1,SIAH2,SIAH3	0.9699	More...