DegronMD

Uniprot ID: Q9NSA2

Source protein: Potassium voltage-gated channel subfamily D member 1

Source gene: KCND1

Class: DEG_Kelch_Keap1_1

Location: 76:81

E3 ligase: KEAP1

DEGRON score: 0.8817

ASA_SCORE: 56.5667

COIL: 0.8493

CONS_SCORE: 0.3035

DSS_SCORE: 0.2183

HELIX: 0.0283

FCONS_SCORE: 0.8478

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S69L	TCGA-AG-A02N	READ	TCGA	DADSGE	DEG_Kelch_Keap1_1	0.1389
p.S69L	DO37146	READ	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.1389
p.F83C	TCGA-AN-A04C	BRCA	TCGA	DADSGE	DEG_Kelch_Keap1_1	0.2778
p.F83C	DO1280	BRCA	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.2778
p.G80D	TCGA-EE-A29L	SKCM	TCGA	DADSGE	DEG_Kelch_Keap1_1	0.7198
p.G80D	DO37835	SKCM	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.7198
p.R86C	TCGA-EM-A2CK	THCA	TCGA	DADSGE	DEG_Kelch_Keap1_1	0.1944
p.R86C	DO39336	THCA	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.1944
p.R86H	DO233693	GACA	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.1944
p.G77S	DO52194	LIHC	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.6993
p.F73L	DO230934	LUSC	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.25
p.G76R	DO220886	MELA	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.7568
p.Q87H	DO41871	UCEC	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.1667
p.E85K	DO42608	UCEC	ICGC	DADSGE	DEG_Kelch_Keap1_1	0.2222
p.D78Y	ACH-000681	Lung Cancer	CCLE	DADSGE	DEG_Kelch_Keap1_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSA2	Potassium voltage-gated channel subfamily D member 1	DEG_Kelch_Keap1_1	76:81	DADSGE	KEAP1	0.8817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons