DegronMD - Q9NSA2(KCND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G620S	TCGA-24-1565	OV	TCGA	PANTPDES	DEG_SCF_FBW7_1	605:612	Mutation rewiring degron network	0.1111
p.S69L	TCGA-AG-A02N	READ	TCGA	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1389
p.S69L	DO37146	READ	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1389
p.F83C	TCGA-AN-A04C	BRCA	TCGA	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.2778
p.F83C	DO1280	BRCA	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.2778
p.S616F	TCGA-EE-A182	SKCM	TCGA	PANTPDES	DEG_SCF_FBW7_1	605:612	Mutation rewiring degron network	0.2222
p.G80D	TCGA-EE-A29L	SKCM	TCGA	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7198
p.G80D	DO37835	SKCM	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7198
p.R86C	TCGA-EM-A2CK	THCA	TCGA	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1944
p.R86C	DO39336	THCA	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1944
p.D610N	TCGA-EO-A22U	UCEC	TCGA	PANTPDES	DEG_SCF_FBW7_1	605:612	Mutation altering degron motif	0.5821
p.R86H	DO233693	GACA	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1944
p.G77S	DO52194	LIHC	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.6993
p.F73L	DO230934	LUSC	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.25
p.G76R	DO220886	MELA	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7568
p.Q87H	DO41871	UCEC	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.E85K	DO42608	UCEC	ICGC	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.2222
p.N607K	ACH-000261	Lung Cancer	CCLE	PANTPDES	DEG_SCF_FBW7_1	605:612	Mutation altering degron motif	0.5806
p.N607K	ACH-002122	Lung Cancer	CCLE	PANTPDES	DEG_SCF_FBW7_1	605:612	Mutation altering degron motif	0.5806
p.D78Y	ACH-000681	Lung Cancer	CCLE	DADSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7325

Kaplan plot for KCND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCND1

UniProt ID: Q9NSA2

Entrez ID: 3750

Protein name: Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCND1 in