DegronMD

Uniprot ID: Q9NSA2

Source protein: Potassium voltage-gated channel subfamily D member 1

Source gene: KCND1

Class: DEG_SCF_FBW7_1

Location: 605:612

E3 ligase: FBXW7

DEGRON score: 0.5843

ASA_SCORE: 92.5375

COIL: 0.9469

CONS_SCORE: 0.2976

DSS_SCORE: 0.7849

HELIX: 0.0363

FCONS_SCORE: 0.9695

RIG_SCORE: 0.5914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G620S	TCGA-24-1565	OV	TCGA	PANTPDES	DEG_SCF_FBW7_1	0.1111
p.S616F	TCGA-EE-A182	SKCM	TCGA	PANTPDES	DEG_SCF_FBW7_1	0.2222
p.D610N	TCGA-EO-A22U	UCEC	TCGA	PANTPDES	DEG_SCF_FBW7_1	0.5821
p.N607K	ACH-000261	Lung Cancer	CCLE	PANTPDES	DEG_SCF_FBW7_1	0.5806
p.N607K	ACH-002122	Lung Cancer	CCLE	PANTPDES	DEG_SCF_FBW7_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSA2	Potassium voltage-gated channel subfamily D member 1	DEG_SCF_FBW7_1	605:612	PANTPDES	FBXW7	0.5843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons