DegronMD

Uniprot ID: P21817

Source protein: Ryanodine receptor 1

Source gene: RYR1

Class: DEG_Kelch_Keap1_1

Location: 4505:4510

E3 ligase: KEAP1

DEGRON score: 0.876

ASA_SCORE: 95.9333

COIL: 0.6742

CONS_SCORE: 0.3734

DSS_SCORE: 0.9127

HELIX: 0.3303

FCONS_SCORE: 1.1565

RIG_SCORE: 0.5024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4520K	TCGA-CK-4951	COAD	TCGA	DAENGE	DEG_Kelch_Keap1_1	0.0556
p.E4507K	TCGA-P3-A6T0	HNSC	TCGA	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.E4507K	SIDM01051	Ovarian Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.E4507K	SIDM01770	Gastric Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.E4507K	ACH-000908	Gastric Cancer	CCLE	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.E4507K	ACH-000936	Ovarian Cancer	CCLE	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.E4507K	EFO-27	ovary	COSMIC	DAENGE	DEG_Kelch_Keap1_1	0.7022
p.G4509E	TCGA-RP-A695	SKCM	TCGA	DAENGE	DEG_Kelch_Keap1_1	0.7199
p.G4509E	DO51270	SKCM	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.7199
p.A4504S	DO234343	ESAD	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.3056
p.P4495L	DO234459	ESAD	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.0556
p.E4505D	DO223071	ESCA	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.6758
p.E4508D	DO233097	GACA	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.6758
p.E4502K	DO49045	HNSC	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.25
p.E4502K	EFO-27	ovary	COSMIC	DAENGE	DEG_Kelch_Keap1_1	0.25
p.V4509F	DO229031	LICA	ICGC	DAENGE	DEG_Kelch_Keap1_1	0.7068
p.P4501L	SIDM00793	Burkitt's Lymphoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	0.2222
p.E4500V	SIDM01609	Endometrial Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21817	Ryanodine receptor 1	DEG_Kelch_Keap1_1	4505:4510	DAENGE	KEAP1	0.876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons