DegronMD - P21817(RYR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1759L	TCGA-60-2714	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.8428
p.R1759L	DO26530	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.8428
p.H1760N	TCGA-64-1676	LUAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6312
p.H1760N	DO23629	LUAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6312
p.T1768I	TCGA-85-8288	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2778
p.T1768I	DO26963	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2778
p.T4461S	TCGA-B5-A3FC	UCEC	TCGA	PPTPEGS	DEG_SCF_FBW7_1	4465:4471	Mutation rewiring degron network	0.2222
p.S1770L	TCGA-BQ-7058	KIRP	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	TCGA-GC-A6I3	BLCA	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	DO219025	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	DO20788	KIRP	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	SIDM01145	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	ACH-000581	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.S1770L	NCI-SNU-16	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.E4520K	TCGA-CK-4951	COAD	TCGA	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.25
p.E4520K	TCGA-CK-4951	COAD	TCGA	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.0556
p.P4522H	TCGA-CN-6010	HNSC	TCGA	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1944
p.H1776Y	TCGA-EE-A29M	SKCM	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.H1776Y	TCGA-EE-A2GJ	SKCM	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.H1776Y	DO220878	MELA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.H1776Y	DO37746	SKCM	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.H1776Y	DO37404	SKCM	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.P4522A	TCGA-FD-A43N	BLCA	TCGA	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1944
p.E4507K	TCGA-P3-A6T0	HNSC	TCGA	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	TCGA-P3-A6T0	HNSC	TCGA	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.E4507K	SIDM01051	Ovarian Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	SIDM01051	Ovarian Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.E4507K	SIDM01770	Gastric Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	SIDM01770	Gastric Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.E4507K	ACH-000908	Gastric Cancer	CCLE	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	ACH-000908	Gastric Cancer	CCLE	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.E4507K	ACH-000936	Ovarian Cancer	CCLE	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	ACH-000936	Ovarian Cancer	CCLE	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.E4507K	EFO-27	ovary	COSMIC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.E4507K	EFO-27	ovary	COSMIC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7022
p.G4509E	TCGA-RP-A695	SKCM	TCGA	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.6087
p.G4509E	TCGA-RP-A695	SKCM	TCGA	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7199
p.G4509E	DO51270	SKCM	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.6087
p.G4509E	DO51270	SKCM	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7199
p.R1759Q	TCGA-VQ-A8PT	STAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.7329
p.R1759Q	DO51776	STAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.7329
p.G1766A	DO48431	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6429
p.P4517A	DO502	BLCA	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.6392
p.E4515K	DO10582	COAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.P1773S	DO229016	COCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00425	Ovarian Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01199	Hepatocellular Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00291	Melanoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00607	Glioblastoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01145	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00562	Breast Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00587	Biliary Tract Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00018	Acute Myeloid Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01682	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00784	Glioma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM00497	Colorectal Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.P1773S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1389
p.A4504S	DO234343	ESAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.25
p.A4504S	DO234343	ESAD	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.3056
p.P4495L	DO234459	ESAD	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.0556
p.E4505D	DO223071	ESCA	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.6758
p.E4508D	DO233097	GACA	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.6758
p.E4508D	DO233097	GACA	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.6758
p.E4502K	DO49045	HNSC	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1944
p.E4502K	DO49045	HNSC	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.25
p.E4502K	EFO-27	ovary	COSMIC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1944
p.E4502K	EFO-27	ovary	COSMIC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.25
p.P4517H	DO14766	HNSC	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7694
p.P1774L	DO229489	LAML	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1111
p.P1774L	DO218861	SKCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1111
p.V4509F	DO229031	LICA	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7068
p.V4509F	DO229031	LICA	ICGC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation altering degron motif	0.7068
p.P4526S	DO222546	MELA	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.0833
p.P4526H	DO46657	PAAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.0833
p.P4526H	RH-1	soft tissue	COSMIC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.0833
p.P4527L	DO219974	SARC	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.0556
p.E4516K	DO229456	SKCA	ICGC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation altering degron motif	0.7022
p.T1769N	DO231495	THCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.25
p.T4456S	DO41871	UCEC	ICGC	PPTPEGS	DEG_SCF_FBW7_1	4465:4471	Mutation rewiring degron network	0.0833
p.P1763S	SIDM01175	Other Sarcomas	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.5641
p.P1763S	SW684	soft tissue	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.5641
p.V1765A	SIDM01146	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6936
p.V1765A	ACH-000932	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6936
p.V1765A	NCI-SNU-1	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6936
p.P1748S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.P1748S	ACH-001362	Lung Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.P1748S	NCI-H1770	lung	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.P4501L	SIDM00793	Burkitt's Lymphoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1667
p.P4501L	SIDM00793	Burkitt's Lymphoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.2222
p.E4500V	SIDM01609	Endometrial Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.1389
p.E4500V	SIDM01609	Endometrial Carcinoma	GDSC	DAENGE	DEG_Kelch_Keap1_1	4505:4510	Mutation rewiring degron network	0.1944
p.H1776Q	SIDM01617	Endometrial Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.H1776Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.0556
p.P4465L	ACH-000301	Leukemia	CCLE	PPTPEGS	DEG_SCF_FBW7_1	4465:4471	Mutation altering degron motif	0.6471
p.D4459E	ACH-001498	Lymphoma	CCLE	PPTPEGS	DEG_SCF_FBW7_1	4465:4471	Mutation rewiring degron network	0.1667
p.P4527Q	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ENGEKEEVPEP	DEG_COP1_1	4507:4517	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RYR1

UniProt ID: P21817

Entrez ID: 6261

Protein name: Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RYR1 in