DegronMD

Uniprot ID: P21817

Source protein: Ryanodine receptor 1

Source gene: RYR1

Class: DEG_COP1_1

Location: 4507:4517

E3 ligase: COP1

DEGRON score: 0.9266

ASA_SCORE: 114.5636

COIL: 0.8314

CONS_SCORE: 0.3337

DSS_SCORE: 0.9052

HELIX: 0.1487

FCONS_SCORE: 1.055

RIG_SCORE: 0.5058

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4517H	DO14766	HNSC	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.7694
p.V4509F	DO229031	LICA	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.7068
p.E4507K	TCGA-P3-A6T0	HNSC	TCGA	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4507K	SIDM01051	Ovarian Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4507K	SIDM01770	Gastric Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4507K	ACH-000908	Gastric Cancer	CCLE	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4507K	ACH-000936	Ovarian Cancer	CCLE	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4507K	EFO-27	ovary	COSMIC	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4515K	DO10582	COAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4516K	DO229456	SKCA	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.7022
p.E4508D	DO233097	GACA	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.6758
p.P4517A	DO502	BLCA	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.6392
p.G4509E	TCGA-RP-A695	SKCM	TCGA	ENGEKEEVPEP	DEG_COP1_1	0.6087
p.G4509E	DO51270	SKCM	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.6087
p.E4520K	TCGA-CK-4951	COAD	TCGA	ENGEKEEVPEP	DEG_COP1_1	0.25
p.A4504S	DO234343	ESAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.25
p.P4522H	TCGA-CN-6010	HNSC	TCGA	ENGEKEEVPEP	DEG_COP1_1	0.1944
p.P4522A	TCGA-FD-A43N	BLCA	TCGA	ENGEKEEVPEP	DEG_COP1_1	0.1944
p.E4502K	DO49045	HNSC	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.1944
p.E4502K	EFO-27	ovary	COSMIC	ENGEKEEVPEP	DEG_COP1_1	0.1944
p.P4501L	SIDM00793	Burkitt's Lymphoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	0.1667
p.E4500V	SIDM01609	Endometrial Carcinoma	GDSC	ENGEKEEVPEP	DEG_COP1_1	0.1389
p.P4526S	DO222546	MELA	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.0833
p.P4526H	DO46657	PAAD	ICGC	ENGEKEEVPEP	DEG_COP1_1	0.0833
p.P4526H	RH-1	soft_tissue	COSMIC	ENGEKEEVPEP	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21817	Ryanodine receptor 1	DEG_COP1_1	4507:4517	ENGEKEEVPEP	COP1	0.9266	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons