DegronMD

Uniprot ID: P21817

Source protein: Ryanodine receptor 1

Source gene: RYR1

Class: DEG_APCC_DBOX_1

Location: 1758:1766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.976

ASA_SCORE: 56.7778

COIL: 0.7443

CONS_SCORE: 0.3955

DSS_SCORE: 0.6283

HELIX: 0.0487

FCONS_SCORE: 1.1321

RIG_SCORE: 0.6114

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1759L	TCGA-60-2714	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.8428
p.R1759L	DO26530	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.8428
p.R1759Q	TCGA-VQ-A8PT	STAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.7329
p.R1759Q	DO51776	STAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.7329
p.V1765A	SIDM01146	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.V1765A	ACH-000932	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.V1765A	NCI-SNU-1	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.G1766A	DO48431	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6429
p.H1760N	TCGA-64-1676	LUAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.6312
p.H1760N	DO23629	LUAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6312
p.P1763S	SIDM01175	Other Sarcomas	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.5641
p.P1763S	SW684	soft_tissue	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.5641
p.T1768I	TCGA-85-8288	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2778
p.T1768I	DO26963	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2778
p.T1769N	DO231495	THCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.25
p.S1770L	TCGA-BQ-7058	KIRP	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	TCGA-GC-A6I3	BLCA	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	DO219025	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	DO20788	KIRP	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	SIDM01145	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	ACH-000581	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	NCI-SNU-16	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.P1773S	DO229016	COCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00425	Ovarian Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01199	Hepatocellular Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389

Showing 1 to 25 of 52 entries

Previous1 2 3Next

Drug responses associated with RYR1 mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of PRHGLPGVG

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21817	Ryanodine receptor 1	DEG_APCC_DBOX_1	1758:1766	PRHGLPGVG	APC,CDC20,FZR1	0.976	More...

Showing 1 to 1 of 1 entries

Previous1Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRHGLPGVG

Degron related mutations and impact score

Drug responses associated with RYR1 mutations

All proteins holding degron of PRHGLPGVG