DegronMD

Uniprot ID: P21817

Source protein: Ryanodine receptor 1

Source gene: RYR1

Class: DEG_APCC_DBOX_1

Location: 1758:1766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.976

ASA_SCORE: 56.7778

COIL: 0.7443

CONS_SCORE: 0.3955

DSS_SCORE: 0.6283

HELIX: 0.0487

FCONS_SCORE: 1.1321

RIG_SCORE: 0.6114

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1759L	TCGA-60-2714	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.8428
p.R1759L	DO26530	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.8428
p.H1760N	TCGA-64-1676	LUAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.6312
p.H1760N	DO23629	LUAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6312
p.T1768I	TCGA-85-8288	LUSC	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2778
p.T1768I	DO26963	LUSC	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2778
p.S1770L	TCGA-BQ-7058	KIRP	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	TCGA-GC-A6I3	BLCA	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	DO219025	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	DO20788	KIRP	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	SIDM01145	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	ACH-000581	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.S1770L	NCI-SNU-16	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.2222
p.H1776Y	TCGA-EE-A29M	SKCM	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Y	TCGA-EE-A2GJ	SKCM	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Y	DO220878	MELA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Y	DO37746	SKCM	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Y	DO37404	SKCM	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.R1759Q	TCGA-VQ-A8PT	STAD	TCGA	PRHGLPGVG	DEG_APCC_DBOX_1	0.7329
p.R1759Q	DO51776	STAD	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.7329
p.G1766A	DO48431	BLCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6429
p.P1773S	DO229016	COCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00425	Ovarian Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01199	Hepatocellular Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00291	Melanoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00607	Glioblastoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01145	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00562	Breast Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00587	Biliary Tract Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00018	Acute Myeloid Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01682	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00784	Glioma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM00497	Colorectal Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1773S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1389
p.P1774L	DO229489	LAML	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1111
p.P1774L	DO218861	SKCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.1111
p.T1769N	DO231495	THCA	ICGC	PRHGLPGVG	DEG_APCC_DBOX_1	0.25
p.P1763S	SIDM01175	Other Sarcomas	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.5641
p.P1763S	SW684	soft_tissue	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.5641
p.V1765A	SIDM01146	Gastric Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.V1765A	ACH-000932	Gastric Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.V1765A	NCI-SNU-1	stomach	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.6936
p.P1748S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.P1748S	ACH-001362	Lung Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.P1748S	NCI-H1770	lung	COSMIC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Q	SIDM01617	Endometrial Carcinoma	GDSC	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556
p.H1776Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRHGLPGVG	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRHGLPGVG

Degron related mutations and impact score

Drug responses associated with RYR1 mutations

All proteins holding degron of PRHGLPGVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21817	Ryanodine receptor 1	DEG_APCC_DBOX_1	1758:1766	PRHGLPGVG	APC,CDC20,FZR1	0.976	More...