DegronMD

Uniprot ID: P21817

Source protein: Ryanodine receptor 1

Source gene: RYR1

Class: DEG_SCF_FBW7_1

Location: 4465:4471

E3 ligase: FBXW7

DEGRON score: 0.988

ASA_SCORE: 82.7286

COIL: 0.946

CONS_SCORE: 0.3974

DSS_SCORE: 0.7935

HELIX: 0.0203

FCONS_SCORE: 1.3038

RIG_SCORE: 0.5832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4461S	TCGA-B5-A3FC	UCEC	TCGA	PPTPEGS	DEG_SCF_FBW7_1	0.2222
p.T4456S	DO41871	UCEC	ICGC	PPTPEGS	DEG_SCF_FBW7_1	0.0833
p.P4465L	ACH-000301	Leukemia	CCLE	PPTPEGS	DEG_SCF_FBW7_1	0.6471
p.D4459E	ACH-001498	Lymphoma	CCLE	PPTPEGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21817	Ryanodine receptor 1	DEG_SCF_FBW7_1	4465:4471	PPTPEGS	FBXW7	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons