DegronMD

Uniprot ID: Q8IX90

Source protein: Spindle and kinetochore-associated protein 3

Source gene: SKA3

Class: CBL_PTK

Location: 277:284

E3 ligase: CBL

DEGRON score: 0.9967

ASA_SCORE: 81.7375

COIL: 0.7766

CONS_SCORE: 0.5336

DSS_SCORE: 0.41

HELIX: 0.1466

FCONS_SCORE: 0.8121

RIG_SCORE: 0.7336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T291I	TCGA-06-5416	GBM	TCGA	DAEYTNSP	CBL_PTK	0.5833
p.T291I	DO10880	GBM	ICGC	DAEYTNSP	CBL_PTK	0.5833
p.Y280F	TCGA-DD-AAC8	LIHC	TCGA	DAEYTNSP	CBL_PTK	0.8639
p.Y280F	DO52193	LIHC	ICGC	DAEYTNSP	CBL_PTK	0.8639
p.Q272K	DO229045	LICA	ICGC	DAEYTNSP	CBL_PTK	0.1944
p.Q272K	DO229006	LICA	ICGC	DAEYTNSP	CBL_PTK	0.1944
p.T281I	DO231832	LINC	ICGC	DAEYTNSP	CBL_PTK	0.8189
p.L294F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DAEYTNSP	CBL_PTK	0.0556
p.L294F	ACH-002215	Lymphoma	CCLE	DAEYTNSP	CBL_PTK	0.0556
p.L294F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	DAEYTNSP	CBL_PTK	0.0556
p.P284H	SIDM01609	Endometrial Carcinoma	GDSC	DAEYTNSP	CBL_PTK	0.7694
p.P284H	ACH-000972	Endometrial/Uterine Cancer	CCLE	DAEYTNSP	CBL_PTK	0.7694
p.L273F	ACH-002017	Eye Cancer	CCLE	DAEYTNSP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX90	Spindle and kinetochore-associated protein 3	CBL_PTK	277:284	DAEYTNSP	CBL	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons