DegronMD - Q8IX90(SKA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T291I	TCGA-06-5416	GBM	TCGA	TNSPLVPTF	DEG_COP1_1	281:289	Mutation blocking phosphorylation signal	0.7222
p.T291I	TCGA-06-5416	GBM	TCGA	DAEYTNSP	CBL_PTK	277:284	Mutation blocking phosphorylation signal	0.5833
p.T291I	DO10880	GBM	ICGC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation blocking phosphorylation signal	0.7222
p.T291I	DO10880	GBM	ICGC	DAEYTNSP	CBL_PTK	277:284	Mutation blocking phosphorylation signal	0.5833
p.E214K	TCGA-17-Z028	LUAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.E214K	TCGA-22-5485	LUSC	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.E214K	DO26553	LUSC	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.Y228F	TCGA-AA-3811	COAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation blocking phosphorylation signal	0.5833
p.Y228F	DO7962	COAD	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation blocking phosphorylation signal	0.5833
p.V216A	TCGA-B5-A11E	UCEC	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation altering degron motif	0.6936
p.V216A	DO41644	UCEC	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation altering degron motif	0.6936
p.M210I	TCGA-B7-5816	STAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.1667
p.M210I	DO38599	STAD	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.1667
p.Y280F	TCGA-DD-AAC8	LIHC	TCGA	DAEYTNSP	CBL_PTK	277:284	Mutation altering degron motif	0.8639
p.Y280F	DO52193	LIHC	ICGC	DAEYTNSP	CBL_PTK	277:284	Mutation altering degron motif	0.8639
p.F213S	TCGA-DF-A2KU	UCEC	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.25
p.F213S	DO223286	UCEC	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.25
p.F213V	TCGA-DK-A6AW	BLCA	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.25
p.F213V	DO48566	BLCA	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.25
p.P297L	TCGA-EE-A3J5	SKCM	TCGA	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1111
p.P297L	DO47331	SKCM	ICGC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1111
p.E214Q	TCGA-VS-A9UH	CESC	TCGA	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.E214Q	DO51642	CESC	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.H222Q	DO229036	LICA	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.3056
p.Q272K	DO229045	LICA	ICGC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.0833
p.Q272K	DO229045	LICA	ICGC	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.1944
p.Q272K	DO229006	LICA	ICGC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.0833
p.Q272K	DO229006	LICA	ICGC	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.1944
p.T281I	DO231832	LINC	ICGC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation altering degron motif	0.8189
p.T281I	DO231832	LINC	ICGC	DAEYTNSP	CBL_PTK	277:284	Mutation altering degron motif	0.8189
p.H222Y	DO232761	PBCA	ICGC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.3056
p.F223I	SIDM01206	Neuroblastoma	GDSC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.F223I	ACH-002248	Neuroblastoma	CCLE	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.F223I	IMR-5	autonomic ganglia	COSMIC	VTPKLE	DEG_SCF_FBW7_2	216:221	Mutation rewiring degron network	0.2778
p.L294F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1944
p.L294F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.0556
p.L294F	ACH-002215	Lymphoma	CCLE	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1944
p.L294F	ACH-002215	Lymphoma	CCLE	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.0556
p.L294F	BC-3	haematopoietic and lymphoid tissue	COSMIC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1944
p.L294F	BC-3	haematopoietic and lymphoid tissue	COSMIC	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.0556
p.P284H	SIDM01609	Endometrial Carcinoma	GDSC	TNSPLVPTF	DEG_COP1_1	281:289	Mutation altering degron motif	0.6583
p.P284H	SIDM01609	Endometrial Carcinoma	GDSC	DAEYTNSP	CBL_PTK	277:284	Mutation altering degron motif	0.7694
p.P284H	ACH-000972	Endometrial/Uterine Cancer	CCLE	TNSPLVPTF	DEG_COP1_1	281:289	Mutation altering degron motif	0.6583
p.P284H	ACH-000972	Endometrial/Uterine Cancer	CCLE	DAEYTNSP	CBL_PTK	277:284	Mutation altering degron motif	0.7694
p.L273F	ACH-002017	Eye Cancer	CCLE	TNSPLVPTF	DEG_COP1_1	281:289	Mutation rewiring degron network	0.1111
p.L273F	ACH-002017	Eye Cancer	CCLE	DAEYTNSP	CBL_PTK	277:284	Mutation rewiring degron network	0.2222

Kaplan plot for SKA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SKA3

UniProt ID: Q8IX90

Entrez ID: 221150

Protein name: Spindle and kinetochore-associated protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SKA3 in