DegronMD

Uniprot ID: Q8IX90

Source protein: Spindle and kinetochore-associated protein 3

Source gene: SKA3

Class: DEG_SCF_FBW7_2

Location: 216:221

E3 ligase: FBXW7

DEGRON score: 0.8346

ASA_SCORE: 74.6333

COIL: 0.7483

CONS_SCORE: 0.6116

DSS_SCORE: 0.1076

HELIX: 0.1505

FCONS_SCORE: 0.814

RIG_SCORE: 0.8546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E214K	TCGA-17-Z028	LUAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.E214K	TCGA-22-5485	LUSC	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.E214K	DO26553	LUSC	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.Y228F	TCGA-AA-3811	COAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.5833
p.Y228F	DO7962	COAD	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.5833
p.V216A	TCGA-B5-A11E	UCEC	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.6936
p.V216A	DO41644	UCEC	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.6936
p.M210I	TCGA-B7-5816	STAD	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.1667
p.M210I	DO38599	STAD	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.1667
p.F213S	TCGA-DF-A2KU	UCEC	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.25
p.F213S	DO223286	UCEC	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.25
p.F213V	TCGA-DK-A6AW	BLCA	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.25
p.F213V	DO48566	BLCA	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.25
p.E214Q	TCGA-VS-A9UH	CESC	TCGA	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.E214Q	DO51642	CESC	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.H222Q	DO229036	LICA	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.3056
p.H222Y	DO232761	PBCA	ICGC	VTPKLE	DEG_SCF_FBW7_2	0.3056
p.F223I	SIDM01206	Neuroblastoma	GDSC	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.F223I	ACH-002248	Neuroblastoma	CCLE	VTPKLE	DEG_SCF_FBW7_2	0.2778
p.F223I	IMR-5	autonomic_ganglia	COSMIC	VTPKLE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX90	Spindle and kinetochore-associated protein 3	DEG_SCF_FBW7_2	216:221	VTPKLE	FBXW7	0.8346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons