DegronMD

Uniprot ID: Q8IX90

Source protein: Spindle and kinetochore-associated protein 3

Source gene: SKA3

Class: DEG_COP1_1

Location: 281:289

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 67.1889

COIL: 0.8394

CONS_SCORE: 0.6916

DSS_SCORE: 0.3765

HELIX: 0.0349

FCONS_SCORE: 1.1517

RIG_SCORE: 0.7738

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T291I	TCGA-06-5416	GBM	TCGA	TNSPLVPTF	DEG_COP1_1	0.7222
p.T291I	DO10880	GBM	ICGC	TNSPLVPTF	DEG_COP1_1	0.7222
p.P297L	TCGA-EE-A3J5	SKCM	TCGA	TNSPLVPTF	DEG_COP1_1	0.1111
p.P297L	DO47331	SKCM	ICGC	TNSPLVPTF	DEG_COP1_1	0.1111
p.Q272K	DO229045	LICA	ICGC	TNSPLVPTF	DEG_COP1_1	0.0833
p.Q272K	DO229006	LICA	ICGC	TNSPLVPTF	DEG_COP1_1	0.0833
p.T281I	DO231832	LINC	ICGC	TNSPLVPTF	DEG_COP1_1	0.8189
p.L294F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	TNSPLVPTF	DEG_COP1_1	0.1944
p.L294F	ACH-002215	Lymphoma	CCLE	TNSPLVPTF	DEG_COP1_1	0.1944
p.L294F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	TNSPLVPTF	DEG_COP1_1	0.1944
p.P284H	SIDM01609	Endometrial Carcinoma	GDSC	TNSPLVPTF	DEG_COP1_1	0.6583
p.P284H	ACH-000972	Endometrial/Uterine Cancer	CCLE	TNSPLVPTF	DEG_COP1_1	0.6583
p.L273F	ACH-002017	Eye Cancer	CCLE	TNSPLVPTF	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX90	Spindle and kinetochore-associated protein 3	DEG_COP1_1	281:289	TNSPLVPTF	COP1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons