DegronMD

Uniprot ID: P30101

Source protein: Protein disulfide-isomerase A3

Source gene: PDIA3

Class: DEG_COP1_1

Location: 435:444

E3 ligase: COP1

DEGRON score: 0.996

ASA_SCORE: 57.41

COIL: 0.848

CONS_SCORE: 0.4948

DSS_SCORE: 0.3459

HELIX: 0.0436

FCONS_SCORE: 1.1947

RIG_SCORE: 0.7402

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A438T	TCGA-D3-A3C7	SKCM	TCGA	DATANDVPSP	DEG_COP1_1	0.6028
p.A438T	TCGA-IB-7651	PAAD	TCGA	DATANDVPSP	DEG_COP1_1	0.6028
p.A438T	DO46657	PAAD	ICGC	DATANDVPSP	DEG_COP1_1	0.6028
p.A438T	DO47569	SKCM	ICGC	DATANDVPSP	DEG_COP1_1	0.6028
p.D435Y	TCGA-DF-A2KU	UCEC	TCGA	DATANDVPSP	DEG_COP1_1	0.7325
p.V430G	DO232761	PBCA	ICGC	DATANDVPSP	DEG_COP1_1	0.1944
p.I453T	SIDM01045	Endometrial Carcinoma	GDSC	DATANDVPSP	DEG_COP1_1	0.0833
p.I453T	ACH-000978	Endometrial/Uterine Cancer	CCLE	DATANDVPSP	DEG_COP1_1	0.0833
p.I453T	EN	endometrium	COSMIC	DATANDVPSP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30101	Protein disulfide-isomerase A3	DEG_COP1_1	435:444	DATANDVPSP	COP1	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons