DegronMD - P30101(PDIA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G113V	TCGA-4Z-AA7M	BLCA	TCGA	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1944
p.P101Q	TCGA-AP-A1DR	UCEC	TCGA	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.2778
p.G117V	TCGA-BR-8372	STAD	TCGA	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.0833
p.A438T	TCGA-D3-A3C7	SKCM	TCGA	DATANDVPSP	DEG_COP1_1	435:444	Mutation altering degron motif	0.6028
p.A438T	TCGA-IB-7651	PAAD	TCGA	DATANDVPSP	DEG_COP1_1	435:444	Mutation altering degron motif	0.6028
p.A438T	DO46657	PAAD	ICGC	DATANDVPSP	DEG_COP1_1	435:444	Mutation altering degron motif	0.6028
p.A438T	DO47569	SKCM	ICGC	DATANDVPSP	DEG_COP1_1	435:444	Mutation altering degron motif	0.6028
p.F106L	TCGA-DC-6154	READ	TCGA	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6981
p.D435Y	TCGA-DF-A2KU	UCEC	TCGA	DATANDVPSP	DEG_COP1_1	435:444	Mutation altering degron motif	0.7325
p.G96E	TCGA-EE-A2MR	SKCM	TCGA	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1389
p.G93V	DO218976	BLCA	ICGC	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.0556
p.Y95F	DO50331	ESAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation blocking phosphorylation signal	0.5556
p.G97V	DO234230	ESAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1667
p.G97V	DO47873	STAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1667
p.Y95N	DO232072	ORCA	ICGC	LKIFRD	LIG_APCC_ABBA_1	103:108	Mutation blocking phosphorylation signal	0.5556
p.V430G	DO232761	PBCA	ICGC	DATANDVPSP	DEG_COP1_1	435:444	Mutation rewiring degron network	0.1944
p.I453T	SIDM01045	Endometrial Carcinoma	GDSC	DATANDVPSP	DEG_COP1_1	435:444	Mutation rewiring degron network	0.0833
p.I453T	ACH-000978	Endometrial/Uterine Cancer	CCLE	DATANDVPSP	DEG_COP1_1	435:444	Mutation rewiring degron network	0.0833
p.I453T	EN	endometrium	COSMIC	DATANDVPSP	DEG_COP1_1	435:444	Mutation rewiring degron network	0.0833

Kaplan plot for PDIA3 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDIA3

UniProt ID: P30101

Entrez ID: 2923

Protein name: Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDIA3 in