DegronMD

Uniprot ID: P30101

Source protein: Protein disulfide-isomerase A3

Source gene: PDIA3

Class: LIG_APCC_ABBA_1

Location: 103:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7786

ASA_SCORE: 34

COIL: 0.277

CONS_SCORE: 0.64

DSS_SCORE: 0.2956

HELIX: 0.0038

FCONS_SCORE: 1.2481

RIG_SCORE: 0.8522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G113V	TCGA-4Z-AA7M	BLCA	TCGA	LKIFRD	LIG_APCC_ABBA_1	0.1944
p.P101Q	TCGA-AP-A1DR	UCEC	TCGA	LKIFRD	LIG_APCC_ABBA_1	0.2778
p.G117V	TCGA-BR-8372	STAD	TCGA	LKIFRD	LIG_APCC_ABBA_1	0.0833
p.F106L	TCGA-DC-6154	READ	TCGA	LKIFRD	LIG_APCC_ABBA_1	0.6981
p.G96E	TCGA-EE-A2MR	SKCM	TCGA	LKIFRD	LIG_APCC_ABBA_1	0.1389
p.G93V	DO218976	BLCA	ICGC	LKIFRD	LIG_APCC_ABBA_1	0.0556
p.Y95F	DO50331	ESAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	0.5556
p.G97V	DO234230	ESAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	0.1667
p.G97V	DO47873	STAD	ICGC	LKIFRD	LIG_APCC_ABBA_1	0.1667
p.Y95N	DO232072	ORCA	ICGC	LKIFRD	LIG_APCC_ABBA_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30101	Protein disulfide-isomerase A3	LIG_APCC_ABBA_1	103:108	LKIFRD	APC,CDC20,FZR1	0.7786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons