DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DATYSKPP
Uniprot ID:
Q765P7
Source protein:
Protein MTSS 2
Source gene:
MTSS2
Class:
CBL_PTK
Location:
334:341
E3 ligase:
CBL
DEGRON score:
0.9982
ASA_SCORE:
81.575
COIL:
0.8575
CONS_SCORE:
0.521
DSS_SCORE:
0.6353
HELIX:
0.0776
FCONS_SCORE:
1.0023
RIG_SCORE:
0.621
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T349A
SIDM00216
Colorectal Carcinoma
GDSC
DATYSKPP
CBL_PTK
0.1111
p.S338F
SIDM00217
Colorectal Carcinoma
GDSC
DATYSKPP
CBL_PTK
0.9093
Drug responses associated with MTSS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DATYSKPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q765P7
Protein MTSS 2
CBL_PTK
334:341
DATYSKPP
CBL
0.9982
More...
