DegronMD

Uniprot ID: Q6UWL2

Source protein: Sushi domain-containing protein 1

Source gene: SUSD1

Class: DEG_COP1_1

Location: 178:189

E3 ligase: COP1

DEGRON score: 0.9404

ASA_SCORE: 69.7

COIL: 0.8315

CONS_SCORE: 0.739

DSS_SCORE: 0.3959

HELIX: 0.0282

FCONS_SCORE: 1.2695

RIG_SCORE: 0.7678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L198Q	TCGA-BF-AAP1	SKCM	TCGA	DCGTPPEVPDGY	DEG_COP1_1	0.0833
p.L198Q	DO219464	SKCM	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.0833
p.G192E	TCGA-DF-A2KU	UCEC	TCGA	DCGTPPEVPDGY	DEG_COP1_1	0.25
p.G192E	DO223286	UCEC	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.25
p.E184K	TCGA-FJ-A3Z7	BLCA	TCGA	DCGTPPEVPDGY	DEG_COP1_1	0.591
p.E184K	DO463	BLCA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.591
p.I190V	TCGA-VS-A8QC	CESC	TCGA	DCGTPPEVPDGY	DEG_COP1_1	0.3056
p.I190V	DO51628	CESC	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.3056
p.P183H	DO229027	LICA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.6583
p.P186T	DO222550	MELA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.7031
p.D170N	DO229224	THCA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	0.1111
p.T172A	SIDM02032	Pancreatic Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.1667
p.I191T	SIDM00216	Colorectal Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.2778
p.I191T	SIDM00584	Osteosarcoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.2778
p.I191T	SIDM00533	Pancreatic Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.2778
p.I191T	SIDM00576	Acute Myeloid Leukemia	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.2778
p.I191T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.2778
p.T175I	SIDM01265	Plasma Cell Myeloma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.25
p.T175I	SIDM00210	Ovarian Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.25
p.T175I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	0.25
p.A171D	ACH-001563	Skin Cancer	CCLE	DCGTPPEVPDGY	DEG_COP1_1	0.1389
p.D170H	ACH-001961	Gallbladder Cancer	CCLE	DCGTPPEVPDGY	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWL2	Sushi domain-containing protein 1	DEG_COP1_1	178:189	DCGTPPEVPDGY	COP1	0.9404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons