DegronMD - Q6UWL2(SUSD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I403F	TCGA-A5-A0G2	UCEC	TCGA	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation altering degron motif	0.6304
p.I403F	DO41235	UCEC	ICGC	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation altering degron motif	0.6304
p.L198Q	TCGA-BF-AAP1	SKCM	TCGA	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.0833
p.L198Q	DO219464	SKCM	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.0833
p.G192E	TCGA-DF-A2KU	UCEC	TCGA	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.25
p.G192E	DO223286	UCEC	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.25
p.E184K	TCGA-FJ-A3Z7	BLCA	TCGA	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation altering degron motif	0.591
p.E184K	DO463	BLCA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation altering degron motif	0.591
p.L413F	TCGA-KQ-A41N	BLCA	TCGA	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1944
p.L413F	DO223588	BLCA	ICGC	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1944
p.D393Y	TCGA-ND-A4WC	UCS	TCGA	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.0556
p.I190V	TCGA-VS-A8QC	CESC	TCGA	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.3056
p.I190V	DO51628	CESC	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.3056
p.R416H	DO233156	GACA	ICGC	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1111
p.R416H	SIDM00397	Acute Myeloid Leukemia	GDSC	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1111
p.R416H	ACH-000195	Leukemia	CCLE	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1111
p.R416H	Set2	haematopoietic and lymphoid tissue	COSMIC	ISIFNE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.1111
p.P183H	DO229027	LICA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation altering degron motif	0.6583
p.P186T	DO222550	MELA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation altering degron motif	0.7031
p.D170N	DO229224	THCA	ICGC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.1111
p.T172A	SIDM02032	Pancreatic Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.1667
p.I191T	SIDM00216	Colorectal Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.2778
p.I191T	SIDM00584	Osteosarcoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.2778
p.I191T	SIDM00533	Pancreatic Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.2778
p.I191T	SIDM00576	Acute Myeloid Leukemia	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.2778
p.I191T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.2778
p.T175I	SIDM01265	Plasma Cell Myeloma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.25
p.T175I	SIDM00210	Ovarian Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.25
p.T175I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.25
p.R12H	ACH-000959	Colon/Colorectal Cancer	CCLE	SRRLLPLLL	DEG_APCC_DBOX_1	11:19	Mutation altering degron motif	0.8244
p.A171D	ACH-001563	Skin Cancer	CCLE	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.1389
p.D170H	ACH-001961	Gallbladder Cancer	CCLE	DCGTPPEVPDGY	DEG_COP1_1	178:189	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUSD1

UniProt ID: Q6UWL2

Entrez ID: 64420

Protein name: Sushi domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUSD1 in