DegronMD

Uniprot ID: Q6UWL2

Source protein: Sushi domain-containing protein 1

Source gene: SUSD1

Class: LIG_APCC_ABBA_1

Location: 403:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8316

ASA_SCORE: 67.6333

COIL: 0.6052

CONS_SCORE: 0.5568

DSS_SCORE: 0.1224

HELIX: 0.0927

FCONS_SCORE: 1.2972

RIG_SCORE: 0.8946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I403F	TCGA-A5-A0G2	UCEC	TCGA	ISIFNE	LIG_APCC_ABBA_1	0.6304
p.I403F	DO41235	UCEC	ICGC	ISIFNE	LIG_APCC_ABBA_1	0.6304
p.L413F	TCGA-KQ-A41N	BLCA	TCGA	ISIFNE	LIG_APCC_ABBA_1	0.1944
p.L413F	DO223588	BLCA	ICGC	ISIFNE	LIG_APCC_ABBA_1	0.1944
p.D393Y	TCGA-ND-A4WC	UCS	TCGA	ISIFNE	LIG_APCC_ABBA_1	0.0556
p.R416H	DO233156	GACA	ICGC	ISIFNE	LIG_APCC_ABBA_1	0.1111
p.R416H	SIDM00397	Acute Myeloid Leukemia	GDSC	ISIFNE	LIG_APCC_ABBA_1	0.1111
p.R416H	ACH-000195	Leukemia	CCLE	ISIFNE	LIG_APCC_ABBA_1	0.1111
p.R416H	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	ISIFNE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWL2	Sushi domain-containing protein 1	LIG_APCC_ABBA_1	403:408	ISIFNE	APC,CDC20,FZR1	0.8316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons