DegronMD

Uniprot ID: O43609

Source protein: Protein sprouty homolog 1

Source gene: SPRY1

Class: CBL_PTK

Location: 235:245

E3 ligase: CBL

DEGRON score: 0.891

ASA_SCORE: 76.7636

COIL: 0.8713

CONS_SCORE: 0.6728

DSS_SCORE: 0.0245

HELIX: 0.0566

FCONS_SCORE: 0.8796

RIG_SCORE: 0.7283

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y241C	TCGA-AG-3906	READ	TCGA	DDEGDSYSDNP	CBL_PTK	0.7087
p.Y241C	DO36491	READ	ICGC	DDEGDSYSDNP	CBL_PTK	0.7087
p.D235N	TCGA-EK-A2PG	CESC	TCGA	DDEGDSYSDNP	CBL_PTK	0.5821
p.D235N	DO49939	CESC	ICGC	DDEGDSYSDNP	CBL_PTK	0.5821
p.P245S	TCGA-FS-A1ZW	SKCM	TCGA	DDEGDSYSDNP	CBL_PTK	0.6752
p.P245S	DO37519	SKCM	ICGC	DDEGDSYSDNP	CBL_PTK	0.6752
p.S247F	TCGA-ND-A4WC	UCS	TCGA	DDEGDSYSDNP	CBL_PTK	0.2778
p.S249L	TCGA-WQ-A9G7	LIHC	TCGA	DDEGDSYSDNP	CBL_PTK	0.2222
p.S249L	DO52326	LIHC	ICGC	DDEGDSYSDNP	CBL_PTK	0.2222
p.E237K	DO222837	MELA	ICGC	DDEGDSYSDNP	CBL_PTK	0.591
p.S255C	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	0.0556
p.S255C	SIDM00541	Colorectal Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	0.0556
p.S255C	ACH-000677	Lung Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	0.0556
p.S255C	ACH-000926	Colon/Colorectal Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	0.0556
p.S255C	HT55	large_intestine	COSMIC	DDEGDSYSDNP	CBL_PTK	0.0556
p.S255C	SW1573	lung	COSMIC	DDEGDSYSDNP	CBL_PTK	0.0556
p.I228V	SIDM00602	Gastric Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	0.1389
p.I228V	ACH-000919	Gastric Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	0.1389
p.I228V	IM-95	stomach	COSMIC	DDEGDSYSDNP	CBL_PTK	0.1389
p.F229S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	DDEGDSYSDNP	CBL_PTK	0.1667
p.F229S	ACH-002241	Leukemia	CCLE	DDEGDSYSDNP	CBL_PTK	0.1667
p.F229S	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	DDEGDSYSDNP	CBL_PTK	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43609	Protein sprouty homolog 1	CBL_PTK	235:245	DDEGDSYSDNP	CBL	0.891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons