DegronMD - O43609(SPRY1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y241C	TCGA-AG-3906	READ	TCGA	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.7087
p.Y241C	DO36491	READ	ICGC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.7087
p.S58L	TCGA-AG-A002	READ	TCGA	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.3056
p.S58L	DO220877	MELA	ICGC	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.3056
p.D235N	TCGA-EK-A2PG	CESC	TCGA	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.5821
p.D235N	DO49939	CESC	ICGC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.5821
p.P245S	TCGA-FS-A1ZW	SKCM	TCGA	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.6752
p.P245S	DO37519	SKCM	ICGC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.6752
p.P57S	TCGA-FW-A3TU	SKCM	TCGA	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.6752
p.P57S	DO37441	SKCM	ICGC	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.6752
p.P57L	TCGA-FW-A3TU	SKCM	TCGA	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.7582
p.P57L	DO37441	SKCM	ICGC	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.7582
p.S247F	TCGA-ND-A4WC	UCS	TCGA	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.2778
p.S249L	TCGA-WQ-A9G7	LIHC	TCGA	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.2222
p.S249L	DO52326	LIHC	ICGC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.2222
p.E237K	DO222837	MELA	ICGC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation altering degron motif	0.591
p.S255C	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.S255C	SIDM00541	Colorectal Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.S255C	ACH-000677	Lung Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.S255C	ACH-000926	Colon/Colorectal Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.S255C	HT55	large intestine	COSMIC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.S255C	SW1573	lung	COSMIC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.0556
p.I228V	SIDM00602	Gastric Carcinoma	GDSC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1389
p.I228V	ACH-000919	Gastric Cancer	CCLE	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1389
p.I228V	IM-95	stomach	COSMIC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1389
p.E52Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.5633
p.E52Q	ACH-000916	Lung Cancer	CCLE	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.5633
p.E52Q	NCI-H1573	lung	COSMIC	NEYTEGP	CBL_PTK	51:57	Mutation altering degron motif	0.5633
p.P65S	SIDM00534	Colorectal Carcinoma	GDSC	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.1111
p.P65S	ACH-000986	Colon/Colorectal Cancer	CCLE	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.1111
p.P65S	HT-115	large intestine	COSMIC	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.1111
p.F229S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1667
p.F229S	ACH-002241	Leukemia	CCLE	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1667
p.F229S	HAL-01	haematopoietic and lymphoid tissue	COSMIC	DDEGDSYSDNP	CBL_PTK	235:245	Mutation rewiring degron network	0.1667
p.D42N	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.0833
p.D42N	ACH-000287	Lymphoma	CCLE	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.0833
p.D42N	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	NEYTEGP	CBL_PTK	51:57	Mutation rewiring degron network	0.0833

Kaplan plot for SPRY1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRY1

UniProt ID: O43609

Entrez ID: 10252

Protein name: Protein sprouty homolog 1 (Spry-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRY1 in