DegronMD

Uniprot ID: O43609

Source protein: Protein sprouty homolog 1

Source gene: SPRY1

Class: CBL_PTK

Location: 51:57

E3 ligase: CBL

DEGRON score: 0.9957

ASA_SCORE: 66.3286

COIL: 0.7164

CONS_SCORE: 0.4845

DSS_SCORE: 0.5396

HELIX: 0.0533

FCONS_SCORE: 1.0442

RIG_SCORE: 0.6353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S58L	TCGA-AG-A002	READ	TCGA	NEYTEGP	CBL_PTK	0.3056
p.S58L	DO220877	MELA	ICGC	NEYTEGP	CBL_PTK	0.3056
p.P57S	TCGA-FW-A3TU	SKCM	TCGA	NEYTEGP	CBL_PTK	0.6752
p.P57S	DO37441	SKCM	ICGC	NEYTEGP	CBL_PTK	0.6752
p.P57L	TCGA-FW-A3TU	SKCM	TCGA	NEYTEGP	CBL_PTK	0.7582
p.P57L	DO37441	SKCM	ICGC	NEYTEGP	CBL_PTK	0.7582
p.E52Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	NEYTEGP	CBL_PTK	0.5633
p.E52Q	ACH-000916	Lung Cancer	CCLE	NEYTEGP	CBL_PTK	0.5633
p.E52Q	NCI-H1573	lung	COSMIC	NEYTEGP	CBL_PTK	0.5633
p.P65S	SIDM00534	Colorectal Carcinoma	GDSC	NEYTEGP	CBL_PTK	0.1111
p.P65S	ACH-000986	Colon/Colorectal Cancer	CCLE	NEYTEGP	CBL_PTK	0.1111
p.P65S	HT-115	large_intestine	COSMIC	NEYTEGP	CBL_PTK	0.1111
p.D42N	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	NEYTEGP	CBL_PTK	0.0833
p.D42N	ACH-000287	Lymphoma	CCLE	NEYTEGP	CBL_PTK	0.0833
p.D42N	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	NEYTEGP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43609	Protein sprouty homolog 1	CBL_PTK	51:57	NEYTEGP	CBL	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons