DegronMD

Uniprot ID: P41161

Source protein: ETS translocation variant 5

Source gene: ETV5

Class: DEG_COP1_1

Location: 65:73

E3 ligase: COP1

DEGRON score: 0.994

ASA_SCORE: 80.2111

COIL: 0.8278

CONS_SCORE: 0.563

DSS_SCORE: 0.513

HELIX: 0.1114

FCONS_SCORE: 1.0552

RIG_SCORE: 0.758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D72Y	TCGA-21-1080	LUSC	TCGA	DDEQFVPDF	DEG_COP1_1	0.7325
p.D72Y	DO26502	LUSC	ICGC	DDEQFVPDF	DEG_COP1_1	0.7325
p.P64S	TCGA-AA-A010	COAD	TCGA	DDEQFVPDF	DEG_COP1_1	0.3056
p.P64S	TCGA-D9-A6EC	SKCM	TCGA	DDEQFVPDF	DEG_COP1_1	0.3056
p.P64S	DO50291	SKCM	ICGC	DDEQFVPDF	DEG_COP1_1	0.3056
p.P64S	SIDM00178	Melanoma	GDSC	DDEQFVPDF	DEG_COP1_1	0.3056
p.P64S	ACH-002386	Skin Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	0.3056
p.L80I	TCGA-EI-6917	READ	TCGA	DDEQFVPDF	DEG_COP1_1	0.1389
p.L80I	DO36881	READ	ICGC	DDEQFVPDF	DEG_COP1_1	0.1389
p.D65V	TCGA-F7-8489	HNSC	TCGA	DDEQFVPDF	DEG_COP1_1	0.7785
p.D65V	DO14319	HNSC	ICGC	DDEQFVPDF	DEG_COP1_1	0.7785
p.P83Q	DO228971	LICA	ICGC	DDEQFVPDF	DEG_COP1_1	0.0556
p.D66N	DO51051	PRAD	ICGC	DDEQFVPDF	DEG_COP1_1	0.5821
p.Q74H	DO229216	THCA	ICGC	DDEQFVPDF	DEG_COP1_1	0.3056
p.F73V	SIDM00534	Colorectal Carcinoma	GDSC	DDEQFVPDF	DEG_COP1_1	0.5957
p.F73V	ACH-000986	Colon/Colorectal Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	0.5957
p.F73V	HT-115	large_intestine	COSMIC	DDEQFVPDF	DEG_COP1_1	0.5957
p.N77D	SIDM00528	Breast Carcinoma	GDSC	DDEQFVPDF	DEG_COP1_1	0.2222
p.N77D	ACH-000934	Breast Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	0.2222
p.N77D	MDA-MB-361	breast	COSMIC	DDEQFVPDF	DEG_COP1_1	0.2222
p.D66Y	ACH-002089	Lung Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	0.6214
p.D66Y	201T	lung	COSMIC	DDEQFVPDF	DEG_COP1_1	0.6214

DegronMD: protein-targeted degradation, mutation and drug response to degrons