DegronMD - P41161(ETV5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D72Y	TCGA-21-1080	LUSC	TCGA	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.7325
p.D72Y	DO26502	LUSC	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.7325
p.P64S	TCGA-AA-A010	COAD	TCGA	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.P64S	TCGA-D9-A6EC	SKCM	TCGA	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.P64S	DO50291	SKCM	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.P64S	SIDM00178	Melanoma	GDSC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.P64S	ACH-002386	Skin Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.P148H	TCGA-AP-A1DK	UCEC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0833
p.P148H	DO42033	UCEC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0833
p.L141V	TCGA-DD-AAC8	LIHC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L141V	DO52193	LIHC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L80I	TCGA-EI-6917	READ	TCGA	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.1389
p.L80I	DO36881	READ	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.1389
p.P140S	TCGA-EY-A215	UCEC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.3056
p.P140S	DO42665	UCEC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.3056
p.D65V	TCGA-F7-8489	HNSC	TCGA	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.7785
p.D65V	DO14319	HNSC	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.7785
p.T144I	TCGA-L5-A891	ESCA	TCGA	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.L141P	DO222602	COCA	ICGC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L141P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L141P	ACH-001183	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L141P	ACH-001497	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.L141P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.2778
p.P83Q	DO228971	LICA	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.0556
p.T139P	DO23398	LINC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation altering degron motif	0.7031
p.D66N	DO51051	PRAD	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.5821
p.Q74H	DO229216	THCA	ICGC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.3056
p.R125G	SIDM00944	Colorectal Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.R125G	ACH-000249	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.R125G	CL-11	large intestine	COSMIC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.P148S	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0833
p.L149V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM00529	Breast Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM01318	Hepatocellular Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.F73V	SIDM00534	Colorectal Carcinoma	GDSC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.5957
p.F73V	ACH-000986	Colon/Colorectal Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.5957
p.F73V	HT-115	large intestine	COSMIC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.5957
p.N77D	SIDM00528	Breast Carcinoma	GDSC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.2222
p.N77D	ACH-000934	Breast Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.2222
p.N77D	MDA-MB-361	breast	COSMIC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation rewiring degron network	0.2222
p.N147K	ACH-000152	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.N147K	ACH-001495	Endometrial/Uterine Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.N147K	ACH-001497	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1111
p.T144P	ACH-000157	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-000247	Gastric Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-000634	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-000760	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001412	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001461	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001550	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001560	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001568	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001970	Metastasis	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-001973	Metastasis	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.T144P	ACH-002023	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1944
p.H145P	ACH-000247	Gastric Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000514	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000647	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000823	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-000866	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-001416	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-001608	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.H145P	ACH-002042	Thyroid Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.1667
p.L149P	ACH-000280	Ovarian Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000296	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000490	Cervical Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000649	Kidney Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000866	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-000869	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001459	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001557	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001608	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001617	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001636	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001648	Prostate Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-001694	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-002024	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.L149P	ACH-002509	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	133:139	Mutation rewiring degron network	0.0556
p.D66Y	ACH-002089	Lung Cancer	CCLE	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.6214
p.D66Y	201T	lung	COSMIC	DDEQFVPDF	DEG_COP1_1	65:73	Mutation altering degron motif	0.6214

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETV5

UniProt ID: P41161

Entrez ID: 2119

Protein name: ETS translocation variant 5 (Ets-related protein ERM)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETV5 in