DegronMD

Uniprot ID: P41161

Source protein: ETS translocation variant 5

Source gene: ETV5

Class: DEG_SCF_FBW7_1

Location: 133:139

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 84.9714

COIL: 0.9356

CONS_SCORE: 0.5653

DSS_SCORE: 0.6783

HELIX: 0.0106

FCONS_SCORE: 1.382

RIG_SCORE: 0.6212

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P148H	TCGA-AP-A1DK	UCEC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	0.0833
p.P148H	DO42033	UCEC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	0.0833
p.L141V	TCGA-DD-AAC8	LIHC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.L141V	DO52193	LIHC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.P140S	TCGA-EY-A215	UCEC	TCGA	PLTPPTT	DEG_SCF_FBW7_1	0.3056
p.P140S	DO42665	UCEC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	0.3056
p.T144I	TCGA-L5-A891	ESCA	TCGA	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.L141P	DO222602	COCA	ICGC	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.L141P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.L141P	ACH-001183	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.L141P	ACH-001497	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.L141P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.2778
p.T139P	DO23398	LINC	ICGC	PLTPPTT	DEG_SCF_FBW7_1	0.7031
p.R125G	SIDM00944	Colorectal Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.R125G	ACH-000249	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.R125G	CL-11	large_intestine	COSMIC	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.P148S	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0833
p.L149V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM00529	Breast Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM01318	Hepatocellular Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.N147K	ACH-000152	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.N147K	ACH-001495	Endometrial/Uterine Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.N147K	ACH-001497	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1111
p.T144P	ACH-000157	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-000247	Gastric Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-000634	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-000760	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001412	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001461	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001550	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001560	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001568	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001970	Metastasis	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-001973	Metastasis	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.T144P	ACH-002023	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1944
p.H145P	ACH-000247	Gastric Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000514	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000647	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000662	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000823	Esophageal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-000866	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-001416	Bladder Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-001569	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-001608	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.H145P	ACH-002042	Thyroid Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.1667
p.L149P	ACH-000280	Ovarian Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000296	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000490	Cervical Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000649	Kidney Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000740	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000866	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-000869	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001229	Primary	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001459	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001557	Lung Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001608	Brain Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001617	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001636	Lymphoma	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001648	Prostate Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-001694	Head and Neck Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-002024	Colon/Colorectal Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556
p.L149P	ACH-002509	Skin Cancer	CCLE	PLTPPTT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPPTT

Degron related mutations and impact score

Drug responses associated with ETV5 mutations

All proteins holding degron of PLTPPTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41161	ETS translocation variant 5	DEG_SCF_FBW7_1	133:139	PLTPPTT	FBXW7	0.9978	More...