DegronMD

Uniprot ID: Q03701

Source protein: CCAAT/enhancer-binding protein zeta

Source gene: CEBPZ

Class: DEG_COP1_1

Location: 926:935

E3 ligase: COP1

DEGRON score: 0.8164

ASA_SCORE: 89.9

COIL: 0.7378

CONS_SCORE: 0.2667

DSS_SCORE: 0.5764

HELIX: 0.2448

FCONS_SCORE: 0.8938

RIG_SCORE: 0.729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M922I	TCGA-A5-A0G2	UCEC	TCGA	DDESESVPEL	DEG_COP1_1	0.2222
p.M922I	DO41235	UCEC	ICGC	DDESESVPEL	DEG_COP1_1	0.2222
p.P933Q	TCGA-BQ-7049	KIRP	TCGA	DDESESVPEL	DEG_COP1_1	0.7035
p.P933Q	DO20853	KIRP	ICGC	DDESESVPEL	DEG_COP1_1	0.7035
p.H938N	TCGA-EB-A24C	SKCM	TCGA	DDESESVPEL	DEG_COP1_1	0.25
p.H938N	DO229045	LICA	ICGC	DDESESVPEL	DEG_COP1_1	0.25
p.H938N	DO37438	SKCM	ICGC	DDESESVPEL	DEG_COP1_1	0.25
p.V932I	SIDM00375	Head and Neck Carcinoma	GDSC	DDESESVPEL	DEG_COP1_1	0.7076
p.V932I	ACH-002305	Head and Neck Cancer	CCLE	DDESESVPEL	DEG_COP1_1	0.7076
p.V932I	SKN-3	upper_aerodigestive_tract	COSMIC	DDESESVPEL	DEG_COP1_1	0.7076
p.D926N	SIDM00999	Bladder Carcinoma	GDSC	DDESESVPEL	DEG_COP1_1	0.6932
p.D926N	ACH-000973	Bladder Cancer	CCLE	DDESESVPEL	DEG_COP1_1	0.6932
p.D926N	639-V	urinary_tract	COSMIC	DDESESVPEL	DEG_COP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03701	CCAAT/enhancer-binding protein zeta	DEG_COP1_1	926:935	DDESESVPEL	COP1	0.8164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons