DegronMD - Q03701(CEBPZ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L186P	TCGA-17-Z022	LUAD	TCGA	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.2222
p.M922I	TCGA-A5-A0G2	UCEC	TCGA	DDESESVPEL	DEG_COP1_1	926:935	Mutation rewiring degron network	0.2222
p.M922I	DO41235	UCEC	ICGC	DDESESVPEL	DEG_COP1_1	926:935	Mutation rewiring degron network	0.2222
p.P933Q	TCGA-BQ-7049	KIRP	TCGA	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.7035
p.P933Q	DO20853	KIRP	ICGC	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.7035
p.K206R	TCGA-DI-A1BU	UCEC	TCGA	NEYSLKP	CBL_PTK	190:196	Mutation substituting flanking lysine	0.1667
p.K206R	DO42023	UCEC	ICGC	NEYSLKP	CBL_PTK	190:196	Mutation substituting flanking lysine	0.1667
p.S193C	TCGA-EA-A43B	CESC	TCGA	NEYSLKP	CBL_PTK	190:196	Mutation altering degron motif	0.7541
p.S193C	DO44384	CESC	ICGC	NEYSLKP	CBL_PTK	190:196	Mutation altering degron motif	0.7541
p.H938N	TCGA-EB-A24C	SKCM	TCGA	DDESESVPEL	DEG_COP1_1	926:935	Mutation rewiring degron network	0.25
p.H938N	DO229045	LICA	ICGC	DDESESVPEL	DEG_COP1_1	926:935	Mutation rewiring degron network	0.25
p.H938N	DO37438	SKCM	ICGC	DDESESVPEL	DEG_COP1_1	926:935	Mutation rewiring degron network	0.25
p.S193Y	TCGA-ND-A4WC	UCS	TCGA	NEYSLKP	CBL_PTK	190:196	Mutation altering degron motif	0.712
p.S193Y	DO8898	COAD	ICGC	NEYSLKP	CBL_PTK	190:196	Mutation altering degron motif	0.712
p.G180A	TCGA-XF-AAML	BLCA	TCGA	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0556
p.G180A	DO51933	BLCA	ICGC	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0556
p.Y205C	DO232761	PBCA	ICGC	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0833
p.G180E	SIDM00669	Pancreatic Carcinoma	GDSC	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0556
p.G180E	ACH-000094	Pancreatic Cancer	CCLE	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0556
p.G180E	HPAF-II	pancreas	COSMIC	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.0556
p.V932I	SIDM00375	Head and Neck Carcinoma	GDSC	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.7076
p.V932I	ACH-002305	Head and Neck Cancer	CCLE	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.7076
p.V932I	SKN-3	upper aerodigestive tract	COSMIC	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.7076
p.D926N	SIDM00999	Bladder Carcinoma	GDSC	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.6932
p.D926N	ACH-000973	Bladder Cancer	CCLE	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.6932
p.D926N	639-V	urinary tract	COSMIC	DDESESVPEL	DEG_COP1_1	926:935	Mutation altering degron motif	0.6932
p.D200G	SIDM01617	Endometrial Carcinoma	GDSC	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.2222
p.E187D	ACH-000690	Lung Cancer	CCLE	NEYSLKP	CBL_PTK	190:196	Mutation rewiring degron network	0.25

Kaplan plot for CEBPZ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEBPZ

UniProt ID: Q03701

Entrez ID: 10153

Protein name: CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEBPZ in