DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
NEYSLKP
Uniprot ID:
Q03701
Source protein:
CCAAT/enhancer-binding protein zeta
Source gene:
CEBPZ
Class:
CBL_PTK
Location:
190:196
E3 ligase:
CBL
DEGRON score:
0.9222
ASA_SCORE:
100
COIL:
0.8591
CONS_SCORE:
0.2118
DSS_SCORE:
0.2793
HELIX:
0.1191
FCONS_SCORE:
0.8102
RIG_SCORE:
0.7569
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L186P
TCGA-17-Z022
LUAD
TCGA
NEYSLKP
CBL_PTK
0.2222
p.K206R
TCGA-DI-A1BU
UCEC
TCGA
NEYSLKP
CBL_PTK
0.1667
p.K206R
DO42023
UCEC
ICGC
NEYSLKP
CBL_PTK
0.1667
p.S193C
TCGA-EA-A43B
CESC
TCGA
NEYSLKP
CBL_PTK
0.7541
p.S193C
DO44384
CESC
ICGC
NEYSLKP
CBL_PTK
0.7541
p.S193Y
TCGA-ND-A4WC
UCS
TCGA
NEYSLKP
CBL_PTK
0.712
p.S193Y
DO8898
COAD
ICGC
NEYSLKP
CBL_PTK
0.712
p.G180A
TCGA-XF-AAML
BLCA
TCGA
NEYSLKP
CBL_PTK
0.0556
p.G180A
DO51933
BLCA
ICGC
NEYSLKP
CBL_PTK
0.0556
p.Y205C
DO232761
PBCA
ICGC
NEYSLKP
CBL_PTK
0.0833
p.G180E
SIDM00669
Pancreatic Carcinoma
GDSC
NEYSLKP
CBL_PTK
0.0556
p.G180E
ACH-000094
Pancreatic Cancer
CCLE
NEYSLKP
CBL_PTK
0.0556
p.G180E
HPAF-II
pancreas
COSMIC
NEYSLKP
CBL_PTK
0.0556
p.D200G
SIDM01617
Endometrial Carcinoma
GDSC
NEYSLKP
CBL_PTK
0.2222
p.E187D
ACH-000690
Lung Cancer
CCLE
NEYSLKP
CBL_PTK
0.25
Drug responses associated with CEBPZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NEYSLKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q03701
CCAAT/enhancer-binding protein zeta
CBL_PTK
190:196
NEYSLKP
CBL
0.9222
More...
