DegronMD

Degron: NEYSLKP

Uniprot ID: Q03701

Source protein: CCAAT/enhancer-binding protein zeta

Source gene: CEBPZ

Class: CBL_PTK

Location: 190:196

E3 ligase: CBL

DEGRON score: 0.9222

ASA_SCORE: 100

COIL: 0.8591

CONS_SCORE: 0.2118

DSS_SCORE: 0.2793

HELIX: 0.1191

FCONS_SCORE: 0.8102

RIG_SCORE: 0.7569

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S193C	TCGA-EA-A43B	CESC	TCGA	NEYSLKP	CBL_PTK	0.7541
p.S193C	DO44384	CESC	ICGC	NEYSLKP	CBL_PTK	0.7541
p.S193Y	TCGA-ND-A4WC	UCS	TCGA	NEYSLKP	CBL_PTK	0.712
p.S193Y	DO8898	COAD	ICGC	NEYSLKP	CBL_PTK	0.712
p.E187D	ACH-000690	Lung Cancer	CCLE	NEYSLKP	CBL_PTK	0.25
p.L186P	TCGA-17-Z022	LUAD	TCGA	NEYSLKP	CBL_PTK	0.2222
p.D200G	SIDM01617	Endometrial Carcinoma	GDSC	NEYSLKP	CBL_PTK	0.2222
p.K206R	TCGA-DI-A1BU	UCEC	TCGA	NEYSLKP	CBL_PTK	0.1667
p.K206R	DO42023	UCEC	ICGC	NEYSLKP	CBL_PTK	0.1667
p.Y205C	DO232761	PBCA	ICGC	NEYSLKP	CBL_PTK	0.0833
p.G180A	TCGA-XF-AAML	BLCA	TCGA	NEYSLKP	CBL_PTK	0.0556
p.G180A	DO51933	BLCA	ICGC	NEYSLKP	CBL_PTK	0.0556
p.G180E	SIDM00669	Pancreatic Carcinoma	GDSC	NEYSLKP	CBL_PTK	0.0556
p.G180E	ACH-000094	Pancreatic Cancer	CCLE	NEYSLKP	CBL_PTK	0.0556
p.G180E	HPAF-II	pancreas	COSMIC	NEYSLKP	CBL_PTK	0.0556

Showing 1 to 15 of 15 entries

Drug responses associated with CEBPZ mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of NEYSLKP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03701	CCAAT/enhancer-binding protein zeta	CBL_PTK	190:196	NEYSLKP	CBL	0.9222	More...

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