DegronMD

Uniprot ID: Q9ULJ8

Source protein: Neurabin-1

Source gene: PPP1R9A

Class: DEG_Kelch_Keap1_1

Location: 628:633

E3 ligase: KEAP1

DEGRON score: 0.7438

ASA_SCORE: 97.7167

COIL: 0.8332

CONS_SCORE: 0.3863

DSS_SCORE: 0.8111

HELIX: 0.1463

FCONS_SCORE: 0.7834

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E618A	TCGA-AA-3715	COAD	TCGA	DDETGE	DEG_Kelch_Keap1_1	0.0556
p.E618A	DO8018	COAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.0556
p.D641H	DO2216	BRCA	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.1111
p.E639D	DO234312	ESAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.1667
p.E630D	DO228952	LICA	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.5647
p.V633M	DO231124	LUSC	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.7208
p.E633K	DO220873	MELA	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.7022
p.D627Y	DO229081	PRAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	0.3056
p.Q619E	SIDM00403	T-Lymphoblastic Leukemia	GDSC	DDETGE	DEG_Kelch_Keap1_1	0.0833
p.Q619E	ACH-000636	Leukemia	CCLE	DDETGE	DEG_Kelch_Keap1_1	0.0833
p.Q619E	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	DDETGE	DEG_Kelch_Keap1_1	0.0833
p.T632P	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	DDETGE	DEG_Kelch_Keap1_1	0.7031
p.T632P	LU-65	lung	COSMIC	DDETGE	DEG_Kelch_Keap1_1	0.7031
p.E618K	SIDM00251	Gastric Carcinoma	GDSC	DDETGE	DEG_Kelch_Keap1_1	0.0556
p.E618K	ACH-000949	Gastric Cancer	CCLE	DDETGE	DEG_Kelch_Keap1_1	0.0556
p.E618K	TGBC11TKB	stomach	COSMIC	DDETGE	DEG_Kelch_Keap1_1	0.0556
p.N642S	ACH-000278	Ovarian Cancer	CCLE	DDETGE	DEG_Kelch_Keap1_1	0.0833
p.E633Q	NCI-H2291	lung	COSMIC	DDETGE	DEG_Kelch_Keap1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULJ8	Neurabin-1	DEG_Kelch_Keap1_1	628:633	DDETGE	KEAP1	0.7438	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons