DegronMD - Q9ULJ8(PPP1R9A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R405W	TCGA-17-Z033	LUAD	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.1944
p.V395M	TCGA-21-1070	LUSC	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation altering degron motif	0.6097
p.V395M	DO27088	LUSC	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation altering degron motif	0.6097
p.E618A	TCGA-AA-3715	COAD	TCGA	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0556
p.E618A	DO8018	COAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0556
p.R831W	TCGA-AJ-A3EK	UCEC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1667
p.R831W	TCGA-EY-A549	UCEC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1667
p.N853Y	TCGA-B0-5696	KIRC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1111
p.S931C	TCGA-BB-7870	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation altering degron motif	0.7541
p.Q849E	TCGA-CN-4723	HNSC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation blocking phosphorylation signal	0.6667
p.E385D	TCGA-D1-A103	UCEC	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.0556
p.E385D	DO42312	UCEC	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.0556
p.Y926C	TCGA-DD-AADV	LIHC	TCGA	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.25
p.R409K	TCGA-DK-A1A7	BLCA	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.0833
p.R409K	DO483	BLCA	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.0833
p.V830A	TCGA-DS-A5RQ	CESC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1389
p.P958L	TCGA-DX-AB2E	SARC	TCGA	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1111
p.P958L	DO220073	SARC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1111
p.S387L	TCGA-EB-A44O	SKCM	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.1111
p.S387L	DO47272	SKCM	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.1111
p.D927N	TCGA-EE-A29D	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.2778
p.D927N	TCGA-GN-A266	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.2778
p.S928T	TCGA-EE-A3J5	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.3056
p.H398Y	TCGA-HU-A4G9	STAD	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation altering degron motif	0.6118
p.H398Y	DO47789	STAD	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation altering degron motif	0.6118
p.N402S	TCGA-SH-A7BD	MESO	TCGA	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.2778
p.D854H	DO225291	BRCA	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0833
p.D641H	DO2216	BRCA	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.1111
p.L953F	DO5626	BRCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.25
p.Q951E	DO5179	BRCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.T953A	DO227996	COCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.25
p.Q951R	DO50439	ESAD	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.3056
p.E639D	DO234312	ESAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.1667
p.Q827E	DO14830	HNSC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.E959G	DO49993	HNSC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.0833
p.N831Y	DO16678	KIRC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1667
p.P929T	DO20823	KIRP	ICGC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation altering degron motif	0.7031
p.A954S	DO22237	LGG	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2222
p.D926E	DO22237	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.25
p.E630D	DO228952	LICA	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.5647
p.D936Y	DO228974	LICA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1111
p.D936Y	DO228974	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.25
p.M397I	DO229027	LICA	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation altering degron motif	0.6507
p.S960I	DO229031	LICA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.0556
p.G939C	DO23740	LUAD	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1944
p.G939C	DO23740	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.1667
p.V828F	DO231078	LUSC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0833
p.V633M	DO231124	LUSC	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.7208
p.P947Q	DO219205	LUSC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.7035
p.I952V	DO228424	MALY	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2778
p.E633K	DO220873	MELA	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.7022
p.R409M	DO50735	ORCA	ICGC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.0833
p.G948E	DO51527	PACA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.6087
p.D627Y	DO229081	PRAD	ICGC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.3056
p.G847W	DO47284	SKCM	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.2778
p.T849I	DO37419	SKCM	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation blocking phosphorylation signal	0.6667
p.N920S	DO51259	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.0833
p.Q619E	SIDM00403	T-Lymphoblastic Leukemia	GDSC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0833
p.Q619E	ACH-000636	Leukemia	CCLE	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0833
p.Q619E	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0833
p.T632P	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.7031
p.T632P	LU-65	lung	COSMIC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.7031
p.L956F	SIDM00216	Colorectal Carcinoma	GDSC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1667
p.L956F	SNU-175	large intestine	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.1667
p.G827A	SIDM00087	Plasma Cell Myeloma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.G827A	SIDM00879	Breast Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.G827A	SIDM00257	Neuroblastoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.G827A	SIDM00628	Breast Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.G827A	SIDM01409	Bladder Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.0556
p.E618K	SIDM00251	Gastric Carcinoma	GDSC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0556
p.E618K	ACH-000949	Gastric Cancer	CCLE	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0556
p.E618K	TGBC11TKB	stomach	COSMIC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0556
p.A837S	SIDM00837	Colorectal Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation altering degron motif	0.7588
p.A837S	ACH-000958	Colon/Colorectal Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation altering degron motif	0.7588
p.A837S	SW48	large intestine	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation altering degron motif	0.7588
p.G847R	SIDM00685	Glioblastoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.2778
p.G847R	ACH-000819	Brain Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.2778
p.G847R	LN-18	central nervous system	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.2778
p.Y404F	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.2222
p.Y404F	ACH-000852	Lung Cancer	CCLE	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.2222
p.Y404F	NCI-H1435	lung	COSMIC	VYMHSD	LIG_APCC_ABBA_1	395:400	Mutation rewiring degron network	0.2222
p.N846S	SIDM00118	Colorectal Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.3056
p.N846S	ACH-001081	Colon/Colorectal Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.3056
p.N846S	HCC2998	large intestine	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.3056
p.N642S	ACH-000278	Ovarian Cancer	CCLE	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation rewiring degron network	0.0833
p.S942F	SW684	soft tissue	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2778
p.S942F	SW684	soft tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.0833
p.L949F	PF-382	haematopoietic and lymphoid tissue	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation altering degron motif	0.587
p.E633Q	NCI-H2291	lung	COSMIC	DDETGE	DEG_Kelch_Keap1_1	628:633	Mutation altering degron motif	0.6744
p.P929L	KYSE-140	oesophagus	COSMIC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation altering degron motif	0.7582
p.L934F	SNU-175	large intestine	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.0556
p.L934F	SNU-175	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.3056
p.S924F	SW684	soft tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.1944
p.M850V	NCI-H446	lung	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation rewiring degron network	0.1944
p.G842A	JJN-3	haematopoietic and lymphoid tissue	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	837:845	Mutation altering degron motif	0.6429
p.N924S	CAL-72	bone	COSMIC	PSSTS	DEG_SPOP_SBC_1	929:933	Mutation rewiring degron network	0.1944
p.A954P	KYSE-70	oesophagus	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	944:950	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R9A

UniProt ID: Q9ULJ8

Entrez ID: 55607

Protein name: Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R9A in