DegronMD

Uniprot ID: Q9ULJ8

Source protein: Neurabin-1

Source gene: PPP1R9A

Class: DEG_APCC_DBOX_1

Location: 837:845

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8679

ASA_SCORE: 81.4889

COIL: 0.6496

CONS_SCORE: 0.4348

DSS_SCORE: 0.5032

HELIX: 0.2426

FCONS_SCORE: 0.9811

RIG_SCORE: 0.7304

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R831W	TCGA-AJ-A3EK	UCEC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	0.1667
p.R831W	TCGA-EY-A549	UCEC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	0.1667
p.N853Y	TCGA-B0-5696	KIRC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	0.1111
p.Q849E	TCGA-CN-4723	HNSC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	0.6667
p.V830A	TCGA-DS-A5RQ	CESC	TCGA	RRTSLGEVS	DEG_APCC_DBOX_1	0.1389
p.D854H	DO225291	BRCA	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0833
p.Q827E	DO14830	HNSC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.N831Y	DO16678	KIRC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.1667
p.V828F	DO231078	LUSC	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0833
p.G847W	DO47284	SKCM	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.2778
p.T849I	DO37419	SKCM	ICGC	RRTSLGEVS	DEG_APCC_DBOX_1	0.6667
p.G827A	SIDM00087	Plasma Cell Myeloma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.G827A	SIDM00879	Breast Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.G827A	SIDM00257	Neuroblastoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.G827A	SIDM00628	Breast Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.G827A	SIDM01409	Bladder Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.0556
p.A837S	SIDM00837	Colorectal Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.7588
p.A837S	ACH-000958	Colon/Colorectal Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	0.7588
p.A837S	SW48	large_intestine	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	0.7588
p.G847R	SIDM00685	Glioblastoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.2778
p.G847R	ACH-000819	Brain Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	0.2778
p.G847R	LN-18	central_nervous_system	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	0.2778
p.N846S	SIDM00118	Colorectal Carcinoma	GDSC	RRTSLGEVS	DEG_APCC_DBOX_1	0.3056
p.N846S	ACH-001081	Colon/Colorectal Cancer	CCLE	RRTSLGEVS	DEG_APCC_DBOX_1	0.3056
p.N846S	HCC2998	large_intestine	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	0.3056
p.M850V	NCI-H446	lung	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	0.1944
p.G842A	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	RRTSLGEVS	DEG_APCC_DBOX_1	0.6429

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRTSLGEVS

Degron related mutations and impact score

Drug responses associated with PPP1R9A mutations

All proteins holding degron of RRTSLGEVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULJ8	Neurabin-1	DEG_APCC_DBOX_1	837:845	RRTSLGEVS	APC,CDC20,FZR1	0.8679	More...