DegronMD

Uniprot ID: Q9ULJ8

Source protein: Neurabin-1

Source gene: PPP1R9A

Class: LIG_APCC_ABBA_1

Location: 395:400

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5729

ASA_SCORE: 76.75

COIL: 0.5878

CONS_SCORE: 0.3434

DSS_SCORE: 0.334

HELIX: 0.1042

FCONS_SCORE: 0.8536

RIG_SCORE: 0.7862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R405W	TCGA-17-Z033	LUAD	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.1944
p.V395M	TCGA-21-1070	LUSC	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.6097
p.V395M	DO27088	LUSC	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.6097
p.E385D	TCGA-D1-A103	UCEC	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.0556
p.E385D	DO42312	UCEC	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.0556
p.R409K	TCGA-DK-A1A7	BLCA	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.0833
p.R409K	DO483	BLCA	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.0833
p.S387L	TCGA-EB-A44O	SKCM	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.1111
p.S387L	DO47272	SKCM	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.1111
p.H398Y	TCGA-HU-A4G9	STAD	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.6118
p.H398Y	DO47789	STAD	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.6118
p.N402S	TCGA-SH-A7BD	MESO	TCGA	VYMHSD	LIG_APCC_ABBA_1	0.2778
p.M397I	DO229027	LICA	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.6507
p.R409M	DO50735	ORCA	ICGC	VYMHSD	LIG_APCC_ABBA_1	0.0833
p.Y404F	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VYMHSD	LIG_APCC_ABBA_1	0.2222
p.Y404F	ACH-000852	Lung Cancer	CCLE	VYMHSD	LIG_APCC_ABBA_1	0.2222
p.Y404F	NCI-H1435	lung	COSMIC	VYMHSD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULJ8	Neurabin-1	LIG_APCC_ABBA_1	395:400	VYMHSD	APC,CDC20,FZR1	0.5729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons