DegronMD

Uniprot ID: Q9ULJ8

Source protein: Neurabin-1

Source gene: PPP1R9A

Class: DEG_SCF_FBW7_1

Location: 944:950

E3 ligase: FBXW7

DEGRON score: 0.9323

ASA_SCORE: 73.7571

COIL: 0.8481

CONS_SCORE: 0.4022

DSS_SCORE: 0.5866

HELIX: 0.0899

FCONS_SCORE: 0.9635

RIG_SCORE: 0.6446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P958L	TCGA-DX-AB2E	SARC	TCGA	PKTPGLS	DEG_SCF_FBW7_1	0.1111
p.P958L	DO220073	SARC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.1111
p.L953F	DO5626	BRCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.25
p.Q951E	DO5179	BRCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.3056
p.T953A	DO227996	COCA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.25
p.Q951R	DO50439	ESAD	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.3056
p.E959G	DO49993	HNSC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.0833
p.A954S	DO22237	LGG	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.2222
p.D936Y	DO228974	LICA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.1111
p.S960I	DO229031	LICA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.0556
p.G939C	DO23740	LUAD	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.1944
p.P947Q	DO219205	LUSC	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.7035
p.I952V	DO228424	MALY	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.2778
p.G948E	DO51527	PACA	ICGC	PKTPGLS	DEG_SCF_FBW7_1	0.6087
p.L956F	SIDM00216	Colorectal Carcinoma	GDSC	PKTPGLS	DEG_SCF_FBW7_1	0.1667
p.L956F	SNU-175	large_intestine	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	0.1667
p.S942F	SW684	soft_tissue	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	0.2778
p.L949F	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	0.587
p.L934F	SNU-175	large_intestine	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	0.0556
p.A954P	KYSE-70	oesophagus	COSMIC	PKTPGLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULJ8	Neurabin-1	DEG_SCF_FBW7_1	944:950	PKTPGLS	FBXW7	0.9323	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons