DegronMD

Uniprot ID: Q9BXL7

Source protein: Caspase recruitment domain-containing protein 11

Source gene: CARD11

Class: CBL_PTK

Location: 603:613

E3 ligase: CBL

DEGRON score: 0.9333

ASA_SCORE: 91.6909

COIL: 0.822

CONS_SCORE: 0.6193

DSS_SCORE: 0.5616

HELIX: 0.1405

FCONS_SCORE: 0.8991

RIG_SCORE: 0.6548

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R608H	TCGA-14-0787	GBM	TCGA	DDSHERYSFGP	CBL_PTK	0.7133
p.R608H	DO13677	GBM	ICGC	DDSHERYSFGP	CBL_PTK	0.7133
p.S614T	TCGA-BQ-7058	KIRP	TCGA	DDSHERYSFGP	CBL_PTK	0.3056
p.S614T	DO20788	KIRP	ICGC	DDSHERYSFGP	CBL_PTK	0.3056
p.S605N	TCGA-BR-4184	STAD	TCGA	DDSHERYSFGP	CBL_PTK	0.5958
p.S605N	DO38328	STAD	ICGC	DDSHERYSFGP	CBL_PTK	0.5958
p.D597N	TCGA-DK-A1AC	BLCA	TCGA	DDSHERYSFGP	CBL_PTK	0.1667
p.D597N	DO514	BLCA	ICGC	DDSHERYSFGP	CBL_PTK	0.1667
p.E607K	TCGA-EE-A29E	SKCM	TCGA	DDSHERYSFGP	CBL_PTK	0.591
p.E607K	DO37831	SKCM	ICGC	DDSHERYSFGP	CBL_PTK	0.591
p.G594S	TCGA-EI-6882	READ	TCGA	DDSHERYSFGP	CBL_PTK	0.0833
p.G594S	DO36531	READ	ICGC	DDSHERYSFGP	CBL_PTK	0.0833
p.S621F	TCGA-HT-7477	LGG	TCGA	DDSHERYSFGP	CBL_PTK	0.1111
p.S621F	DO48594	LGG	ICGC	DDSHERYSFGP	CBL_PTK	0.1111
p.H623Q	DO229029	LICA	ICGC	DDSHERYSFGP	CBL_PTK	0.0556
p.S620F	DO222843	MELA	ICGC	DDSHERYSFGP	CBL_PTK	0.1389
p.S593N	DO228734	PRAD	ICGC	DDSHERYSFGP	CBL_PTK	0.5
p.S610C	DO46824	RECA	ICGC	DDSHERYSFGP	CBL_PTK	0.7541
p.H606N	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	0.6312
p.H606N	ACH-000521	Lung Cancer	CCLE	DDSHERYSFGP	CBL_PTK	0.6312
p.H606N	NCI-H2030	lung	COSMIC	DDSHERYSFGP	CBL_PTK	0.6312
p.H617R	SIDM00878	Breast Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	0.2222
p.H617R	ACH-000930	Breast Cancer	CCLE	DDSHERYSFGP	CBL_PTK	0.2222
p.H617R	HCC1569	breast	COSMIC	DDSHERYSFGP	CBL_PTK	0.2222
p.S610F	SIDM00683	Prostate Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	0.7982
p.S610F	ACH-000977	lymph_node	CCLE	DDSHERYSFGP	CBL_PTK	0.7982
p.S610F	LNCaP-Clone-FGC	prostate	COSMIC	DDSHERYSFGP	CBL_PTK	0.7982
p.S605G	ACH-000251	Lung Cancer	CCLE	DDSHERYSFGP	CBL_PTK	0.5882
p.S618A	ACH-001991	Primary	CCLE	DDSHERYSFGP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL7	Caspase recruitment domain-containing protein 11	CBL_PTK	603:613	DDSHERYSFGP	CBL	0.9333	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DDSHERYSFGP

Degron related mutations and impact score

Drug responses associated with CARD11 mutations

All proteins holding degron of DDSHERYSFGP