DegronMD - Q9BXL7(CARD11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R608H	TCGA-14-0787	GBM	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7133
p.R608H	DO13677	GBM	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7133
p.F490V	TCGA-B5-A0JY	UCEC	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.F490V	DO43041	UCEC	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.S614T	TCGA-BQ-7058	KIRP	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.3056
p.S614T	DO20788	KIRP	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.3056
p.S605N	TCGA-BR-4184	STAD	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.5958
p.S605N	DO38328	STAD	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.5958
p.R498H	TCGA-D1-A103	UCEC	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7133
p.R498H	DO42312	UCEC	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7133
p.D597N	TCGA-DK-A1AC	BLCA	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1667
p.D597N	DO514	BLCA	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1667
p.E607K	TCGA-EE-A29E	SKCM	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.591
p.E607K	DO37831	SKCM	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.591
p.G594S	TCGA-EI-6882	READ	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.0833
p.G594S	DO36531	READ	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.0833
p.P495Q	TCGA-FS-A1ZP	SKCM	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.P495Q	DO37703	SKCM	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.Q508H	TCGA-GN-A265	SKCM	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.Q508H	DO37491	SKCM	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.S621F	TCGA-HT-7477	LGG	TCGA	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1111
p.S621F	DO48594	LGG	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1111
p.S512P	DO233622	GACA	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation blocking phosphorylation signal	0.6111
p.H623Q	DO229029	LICA	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.0556
p.R498P	DO50846	LICA	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6401
p.S620F	DO222843	MELA	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1389
p.S593N	DO228734	PRAD	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation blocking phosphorylation signal	0.5
p.S610C	DO46824	RECA	ICGC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7541
p.A510V	SIDM00216	Colorectal Carcinoma	GDSC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.A510V	ACH-000989	Colon/Colorectal Cancer	CCLE	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.A510V	SNU-175	large intestine	COSMIC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.H606N	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.6312
p.H606N	ACH-000521	Lung Cancer	CCLE	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.6312
p.H606N	NCI-H2030	lung	COSMIC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.6312
p.R498L	SIDM00282	Colorectal Carcinoma	GDSC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7316
p.R498L	ACH-000998	Colon/Colorectal Cancer	CCLE	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7316
p.R498L	CW-2	large intestine	COSMIC	RRMNLKGIQ	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7316
p.H617R	SIDM00878	Breast Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.2222
p.H617R	ACH-000930	Breast Cancer	CCLE	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.2222
p.H617R	HCC1569	breast	COSMIC	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.2222
p.S610F	SIDM00683	Prostate Carcinoma	GDSC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7982
p.S610F	ACH-000977	lymph node	CCLE	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7982
p.S610F	LNCaP-Clone-FGC	prostate	COSMIC	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.7982
p.S605G	ACH-000251	Lung Cancer	CCLE	DDSHERYSFGP	CBL_PTK	603:613	Mutation altering degron motif	0.5882
p.S618A	ACH-001991	Primary	CCLE	DDSHERYSFGP	CBL_PTK	603:613	Mutation rewiring degron network	0.1944

Kaplan plot for CARD11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CARD11

UniProt ID: Q9BXL7

Entrez ID: 84433

Protein name: Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CARD11 in