DegronMD

Uniprot ID: Q9BXL7

Source protein: Caspase recruitment domain-containing protein 11

Source gene: CARD11

Class: DEG_APCC_DBOX_1

Location: 498:506

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9471

ASA_SCORE: 89.4889

COIL: 0.5672

CONS_SCORE: 0.7115

DSS_SCORE: 0.6396

HELIX: 0.2818

FCONS_SCORE: 1.1134

RIG_SCORE: 0.7373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F490V	TCGA-B5-A0JY	UCEC	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	0.1111
p.F490V	DO43041	UCEC	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.1111
p.R498H	TCGA-D1-A103	UCEC	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	0.7133
p.R498H	DO42312	UCEC	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.7133
p.P495Q	TCGA-FS-A1ZP	SKCM	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	0.25
p.P495Q	DO37703	SKCM	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.25
p.Q508H	TCGA-GN-A265	SKCM	TCGA	RRMNLKGIQ	DEG_APCC_DBOX_1	0.2778
p.Q508H	DO37491	SKCM	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.2778
p.S512P	DO233622	GACA	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.6111
p.R498P	DO50846	LICA	ICGC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.6401
p.A510V	SIDM00216	Colorectal Carcinoma	GDSC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.2222
p.A510V	ACH-000989	Colon/Colorectal Cancer	CCLE	RRMNLKGIQ	DEG_APCC_DBOX_1	0.2222
p.A510V	SNU-175	large_intestine	COSMIC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.2222
p.R498L	SIDM00282	Colorectal Carcinoma	GDSC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.7316
p.R498L	ACH-000998	Colon/Colorectal Cancer	CCLE	RRMNLKGIQ	DEG_APCC_DBOX_1	0.7316
p.R498L	CW-2	large_intestine	COSMIC	RRMNLKGIQ	DEG_APCC_DBOX_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL7	Caspase recruitment domain-containing protein 11	DEG_APCC_DBOX_1	498:506	RRMNLKGIQ	APC,CDC20,FZR1	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons