DegronMD

Uniprot ID: O95070

Source protein: Protein YIF1A

Source gene: YIF1A

Class: CBL_PTK

Location: 27:37

E3 ligase: CBL

DEGRON score: 0.9878

ASA_SCORE: 66.9273

COIL: 0.9377

CONS_SCORE: 0.289

DSS_SCORE: 0.6178

HELIX: 0.0329

FCONS_SCORE: 0.951

RIG_SCORE: 0.606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A19V	TCGA-04-1331	OV	TCGA	DDTSGGYSSQP	CBL_PTK	0.1111
p.A19V	DO28119	OV	ICGC	DDTSGGYSSQP	CBL_PTK	0.1111
p.A19V	DO41871	UCEC	ICGC	DDTSGGYSSQP	CBL_PTK	0.1111
p.A45S	TCGA-61-1914	OV	TCGA	DDTSGGYSSQP	CBL_PTK	0.1111
p.A45S	DO28105	OV	ICGC	DDTSGGYSSQP	CBL_PTK	0.1111
p.G38R	TCGA-AA-3492	COAD	TCGA	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	DO8224	COAD	ICGC	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	SIDM00079	Ovarian Carcinoma	GDSC	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	ACH-000811	Ovarian Cancer	CCLE	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	ACH-002256	Leukemia	CCLE	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	SK-OV-3	ovary	COSMIC	DDTSGGYSSQP	CBL_PTK	0.3056
p.G38R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DDTSGGYSSQP	CBL_PTK	0.3056
p.G31S	TCGA-BH-A0HQ	BRCA	TCGA	DDTSGGYSSQP	CBL_PTK	0.5882
p.G31S	DO3082	BRCA	ICGC	DDTSGGYSSQP	CBL_PTK	0.5882
p.Y40S	DO48438	BLCA	ICGC	DDTSGGYSSQP	CBL_PTK	0.25
p.A42T	DO884	BOCA	ICGC	DDTSGGYSSQP	CBL_PTK	0.1944
p.D27N	DO222864	COCA	ICGC	DDTSGGYSSQP	CBL_PTK	0.5821
p.V18M	DO233867	GACA	ICGC	DDTSGGYSSQP	CBL_PTK	0.0833
p.T43K	DO229037	LICA	ICGC	DDTSGGYSSQP	CBL_PTK	0.1667
p.D46Y	DO232761	PBCA	ICGC	DDTSGGYSSQP	CBL_PTK	0.0833
p.G46W	DO37778	SKCM	ICGC	DDTSGGYSSQP	CBL_PTK	0.0833
p.I31M	RKO	large_intestine	COSMIC	DDTSGGYSSQP	CBL_PTK	0.7618
p.A39D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DDTSGGYSSQP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95070	Protein YIF1A	CBL_PTK	27:37	DDTSGGYSSQP	CBL	0.9878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons